乳香酸（BA）在癌症治疗、免疫反应调节和抗炎治疗中显示出良好的效果。我们的目的是评估α-BA（α-BA）在治疗急性伤口愈合中的作用。建立体内伤口愈合模型来评估α-BA的治疗效果。进行细胞测定以评估 α-BA 对细胞生物学功能的影响。采用Western blot分析验证α-BA的潜在作用机制。动物模型表明，与对照组相比，α-BA组的伤口愈合明显加速（P < 0.01）。苏木精和伊红（HE）染色以及酶联免疫吸附测定（ELISA）测定初步提示α-BA可能通过抑制过度炎症反应和增加生长因子的蛋白水平来加速伤口愈合。细胞功能实验表明，α-BA可抑制人肥厚性疤痕成纤维细胞（HSFB）的增殖和迁移能力，从而有利于伤口愈合。此外，α-BA 对细胞周期进程具有显着影响。从机制上讲，α-BA 下调了核因子 kappa beta (NF-κB) 信号通路中关键基因的蛋白水平，包括细胞周期蛋白 D1、p65、IκBα 和 p-IκBα。皮肤疤痕组织异常增殖，从而加速伤口愈合。这些发现表明其作为治疗急性伤口愈合的新药物具有开发潜力。版权所有：© 2024 Dong 等人。这是一篇根据知识共享署名许可条款分发的开放获取文章，允许在任何媒体上不受限制地使用、分发和复制，前提是注明原始作者和来源。

Boswellic acids (BAs) showed promising effects in cancer treatment, immune response regulation, and anti-inflammatory therapy. We aimed to assess the roles of alpha-BA (α-BA) in treating acute wound healing.In vivo wound-healing models were established to evaluate the therapeutic effects of α-BA. Cell assays were conducted to assess the impact of α-BA on cellular biological functions. Western blot analysis was employed to validate the potential mechanisms of action of α-BA.Animal models indicated that wound healing was notably accelerated in the α-BA group compared to the control group (P < 0.01). Hematoxylin and eosin (HE) staining and enzyme-linked immunosorbent assay (ELISA) assay preliminarily suggested that α-BA may accelerate wound healing by inhibiting excessive inflammatory reactions and increasing the protein levels of growth factors. Cell function experiments demonstrated that α-BA suppressed the proliferation and migration ability of human hypertrophic scar fibroblasts (HSFBs), thereby favoring wound healing. Additionally, α-BA exerted a significant impact on cell cycle progression. Mechanistically, the protein levels of key genes in nuclear factor kappa beta (NF-κB) signaling pathway, including cyclin D1, p65, IκBα, and p-IκBα, were downregulated by α-BA.α-BA demonstrated the ability to counteract the abnormal proliferation of skin scar tissues, consequently expediting wound healing. These findings suggest its potential for development as a new agent for treating acute wound healing.Copyright: © 2024 Dong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.