最近发现中枢神经系统（CNS）在控制肿瘤发生和进展中的关键作用，开辟了一个新的研究领域。越来越多的证据表明大脑和肿瘤之间存在双向相互作用。大脑通过涉及周围神经系统、内分泌系统和免疫系统的复杂神经网络影响肿瘤细胞的生物学行为，而肿瘤可以建立局部自主神经和感觉神经网络，将信号传递到中枢神经系统，从而影响大脑活动。本文旨在总结脑肿瘤串扰的最新研究成果，探讨脑与各种外周实体瘤之间的神经回路，分析在肿瘤发生发展中的作用以及相关的分子介质和病理机制，并强调其对理解脑肿瘤串扰的关键影响。癌症生物学。增强对大脑和肿瘤之间相互沟通的理解将为进一步研究奠定坚实的理论基础，并可能为重新利用癌症治疗中的精神干预措施开辟途径。

The recent discovery of the pivotal role of central nervous system (CNS) in controlling tumor initiation and progression has opened a new field of research. Increasing evidence suggests a bidirectional interaction between the brain and tumors. The brain influences the biological behavior of tumor cells through complex neural networks involving the peripheral nervous system, the endocrine system, and the immune system, while tumors can establish local autonomic and sensory neural networks to transmit signals into the CNS, thereby affecting brain activity. This review aims to summarize the latest research in brain-tumor crosstalk, exploring neural circuitries between the brain and various peripheral solid tumors, analyzing the roles in tumor development and the related molecular mediators and pathological mechanisms, and highlighting the critical impact on the understanding of cancer biology. Enhanced understanding of reciprocal communication between the brain and tumors will establish a solid theoretical basis for further research and could open avenues for repurposing psychiatric interventions in cancer treatment.