RGS（G 蛋白信号传导调节器）蛋白长期以来一直吸引着研究人员的关注，因为它们复杂地参与细胞系统内的多种信号传导途径。它们多样化且微妙的功能使它们成为科学探究的持续主题，特别是考虑到某些家庭成员在各种癌症类型中的影响。在这方面特别值得注意的是 RGS20，我们最近研究了其在肝细胞癌中的临床相关性和分子意义。这些研究引发了人们对 RGS20 基因内致病性突变的普遍性以及相互作用蛋白的复杂网络的质疑，这些突变可能导致癌症生物学的复杂景观。在我们的研究中，我们的目标是揭示 RGS20 基因内的突变以及 RGS20 与癌症背景下其他蛋白质之间的多方面相互作用。我们的研究致力于探索 RGS20 在各种癌症中的复杂机制，从而扩展这一研究方向。特别是，我们将注意力转向研究 RGS20 在血液恶性肿瘤中的作用，特别关注多发性骨髓瘤和滤泡性淋巴瘤。这些血液癌症对于进一步研究具有重要意义，因为了解 RGS20 参与其发病机制可以揭示新的治疗策略和治疗途径。此外，我们的探索已扩展到涵盖 RGS20 可能参与影响中枢神经系统的疾病的最新发现，从而将其影响范围扩大到肿瘤学之外，涵盖神经生物学和相关领域。© 2024。作者。

RGS (Regulator of G protein signaling) proteins have long captured the fascination of researchers due to their intricate involvement across a wide array of signaling pathways within cellular systems. Their diverse and nuanced functions have positioned them as continual subjects of scientific inquiry, especially given the implications of certain family members in various cancer types. Of particular note in this context is RGS20, whose clinical relevance and molecular significance in hepatocellular carcinoma we have recently investigated. These investigations have prompted questions into the prevalence of pathogenic mutations within the RGS20 gene and the intricate network of interacting proteins that could contribute to the complex landscape of cancer biology. In our study, we aim to unravel the mutations within the RGS20 gene and the multifaceted interplay between RGS20 and other proteins within the context of cancer. Expanding on this line of inquiry, our research is dedicated to uncovering the intricate mechanisms of RGS20 in various cancers. In particular, we have redirected our attention to examining the role of RGS20 within hematological malignancies, with a specific focus on multiple myeloma and follicular lymphoma. These hematological cancers hold significant promise for further investigation, as understanding the involvement of RGS20 in their pathogenesis could unveil novel therapeutic strategies and treatment avenues. Furthermore, our exploration has extended to encompass the latest discoveries concerning the potential involvement of RGS20 in diseases affecting the central nervous system, thereby broadening the scope of its implications beyond oncology to encompass neurobiology and related fields.© 2024. The Author(s).