肠上皮经历持续的稳态更新以进行营养物质的消化和吸收。同时，肠上皮屏障将宿主与肠腔分开，防止肠道病原体的全身感染。为了维持体内平衡和上皮功能，位于肠隐窝底部的干细胞会产生祖细胞，这些祖细胞最终分化产生一系列分泌细胞和吸收细胞。肠道再生受到生态位信号通路的调节，特别是 Wnt、骨形态发生蛋白、Notch 和表皮生长因子。此外，生长因子和其他肽通过其在细胞增殖、分化、迁移和存活中的作用，已成为肠道修复和炎症的潜在调节剂。溶血磷脂酸（LPA）是调节上皮细胞增殖、存活和迁移的因子，同时还调节免疫细胞的运输，这两者对于组织稳态都很重要。然而，LPA 信号传导的扰动已被证明会促进癌症和炎症。本综述重点关注 LPA 介导的信号传导的最新进展，这些信号有助于胃肠系统的生理和病理生理调节。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

The intestinal epithelium undergoes continuous homeostatic renewal to conduct the digestion and absorption of nutrients. At the same time, the intestinal epithelial barrier separates the host from the intestinal lumen, preventing systemic infection from enteric pathogens. To maintain homeostasis and epithelial functionality, stem cells, which reside in the base of intestinal crypts, generate progenitor cells that ultimately differentiate to produce an array of secretory and absorptive cells. Intestinal regeneration is regulated by niche signaling pathways, specifically, Wnt, bone morphogenetic protein, Notch, and epidermal growth factor. In addition, growth factors and other peptides have emerged as potential modulators of intestinal repair and inflammation through their roles in cellular proliferation, differentiation, migration, and survival. Lysophosphatidic acid (LPA) is such a factor that modulates the proliferation, survival, and migration of epithelial cells while also regulating trafficking of immune cells, both of which are important for tissue homeostasis. Perturbation of LPA signaling, however, has been shown to promote cancer and inflammation. This review focuses on the recent advances in LPA-mediated signaling that contribute to physiological and pathophysiological regulation of the gastrointestinal system.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.