期待通过癌症靶向巨噬细胞在血液癌中靶向巨噬细胞
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers
影响因子:4.40000
分区:医学2区 / 药学2区
发表日期:2024 Sep
作者:
David Kegyes, Paul Alexandru Milea, Andreea-Isabella Mazga, Adrian-Bogdan Tigu, Madalina Nistor, Diana Cenariu, Radu Tomai, Sanda Buruiana, Hermann Einsele, Alina Daniela Tănase, Ciprian Tomuleasa
摘要
骨髓微环境（BME）对于健康造血至关重要，并且在血液学恶性肿瘤中经常受到干扰。肿瘤相关的巨噬细胞（TAM）是肿瘤微环境（TME）的主要细胞类型，在肿瘤生长和进展中起着重要作用。 Targeting TAMs and modulating their polarization is a promising strategy for cancer therapy.In this review, we discuss the importance of TME and different multiple possible targets to modulate immunosuppressive TAMs such as: CD123, Sphingosine 1-Phosphate Receptors, CD19/CD1d, CCR4/CCL22, CSF1R (CD115), CD24, CD40, B7 family proteins, Marco，CD47，CD163，CD204，CD206和叶酸受体。在血液学恶性肿瘤中抗击肿瘤微环境的免疫抑制环境的方法，可能具有很高的临床意义，并且可能导致癌症毒性的生存质量提高，生存质量的提高，癌症的毒性提高。标准程序可能会涉及CAR T/NK细胞疗法与其他治疗的结合，从而导致更全面的癌症护理。
Abstract
The bone marrow microenvironment (BME) is critical for healthy hematopoiesis and is often disrupted in hematologic malignancies. Tumor-associated macrophages (TAMs) are a major cell type in the tumor microenvironment (TME) and play a significant role in tumor growth and progression. Targeting TAMs and modulating their polarization is a promising strategy for cancer therapy.In this review, we discuss the importance of TME and different multiple possible targets to modulate immunosuppressive TAMs such as: CD123, Sphingosine 1-Phosphate Receptors, CD19/CD1d, CCR4/CCL22, CSF1R (CD115), CD24, CD40, B7 family proteins, MARCO, CD47, CD163, CD204, CD206 and folate receptors.Innovative approaches to combat the immunosuppressive milieu of the tumor microenvironment in hematologic malignancies are of high clinical significance and may lead to increased survival, improved quality of life, and decreased toxicity of cancer therapies. Standard procedures will likely involve a combination of CAR T/NK-cell therapies with other treatments, leading to more comprehensive cancer care.