据报道，2 型糖尿病 (T2D) 与乳腺癌风险之间存在关联。这种关联可以通过胰岛素/IGF 系统的改变来解释。因此，我们的目的是前瞻性地调查先前报道的与 T2D 呈负相关的饮食糖尿病风险评分 (DDS) 是否也与 SUN（“Seguimiento Universidad de Navarra”）队列中的乳腺癌风险相关。我们对 10,810 名女性（平均年龄 = 35 岁，SD = 11 岁）进行了平均 12.5 年的随访，期间诊断出 147 例新的浸润性乳腺癌病例。在基线和 10 年随访后进行了经过验证的 136 项 FFQ。 DDS（范围：11 至 55 分）正权重蔬菜、水果、全麦食品、坚果、咖啡、低脂乳制品、纤维、PUFA；而红肉、加工肉类和含糖饮料则为负权重。 DDS 被分为三分位数。自我报告的医学诊断乳腺癌病例通过医疗记录得到证实。我们发现 DDS 评分的中间三分位数与总体乳腺癌风险（风险比，HRT2 与 T1= 0.55；95% CI：0.36-0.82）和绝经前乳腺癌风险（HRT2= 0.26；95%）之间存在显着的负相关。 CI：0.13-0.53），但不适用于最高三分位。这种关联在 BMI< 25 kg/m2 的女性中更为明显（pinteraction：0.029）。总之，适度遵守 DDS 评分与降低乳腺癌风险相关，尤其是绝经前女性和体重指数较低的女性。这些发现强调了抗糖尿病饮食在降低乳腺癌风险方面的重要性。© 2024。作者。

An association between type 2 diabetes (T2D) and breast cancer risk has been reported. This association can be potentially explained by alteration of the insulin/IGF system. Therefore, we aimed to prospectively investigate whether a previously reported Dietary-Based Diabetes Risk Score (DDS) inversely associated with T2D was also associated with breast cancer risk in the SUN ("Seguimiento Universidad de Navarra") cohort. We followed up 10,810 women (mean age = 35 years, SD = 11 years) for an average of 12.5 years during which 147 new cases of invasive breast cancer were diagnosed. A validated 136-item FFQ was administered at baseline and after 10 years of follow-up. The DDS (range: 11 to 55 points) positively weighted vegetables, fruit, whole cereals, nuts, coffee, low-fat dairy, fiber, PUFA; while it negatively weighted red meat, processed meats, and sugar-sweetened beverages. The DDS was categorized into tertiles. Self-reported medically diagnosed breast cancer cases were confirmed through medical records. We found a significant inverse association between the intermediate tertile of the DDS score and overall breast cancer risk (Hazard ratio, HRT2 vs. T1= 0.55; 95% CI: 0.36-0.82) and premenopausal breast cancer risk (HRT2= 0.26; 95% CI: 0.13-0.53), but not for the highest tertile. This association was stronger among women with a BMI < 25 kg/m2 (pinteraction: 0.029). In conclusion, moderate adherence to the DDS score was associated with a lower risk of breast cancer, especially among premenopausal women and women with a lower BMI. These findings underscore the importance of antidiabetic diet in reducing the risk of breast cancer.© 2024. The Author(s).