乙型肝炎是由乙型肝炎病毒 (HBV) 引起的肝脏感染，可发展为慢性感染，使患者面临因肝硬化和肝癌死亡的高风险。在本研究中，我们旨在通过使用 FUMA 中的基因功能分析来研究男性和女性之间反应组前 Notch 表达和加工的差异。我们分析了台湾生物银行 (TWB) 收集的 48,874 名女性和 23,178 名男性个体的数据2008年至2019年，在全基因组关联研究（GWAS）分析中，根据血液学乙型肝炎表面抗原（HBsAg）状态，将阳性和阴性分为病例和对照。我们发现了4715名女性和2656名男性HBV病例。男性和女性的基因组风险位点不同。在男性中，检测到 3 个风险位点（rs3732421、rs1884575 和 Affx-28516147），同时检测到 8 个风险位点（Affx-4564106、rs932745、rs7574865、rs34050244、rs77041685、rs107822、rs2296651 和 rs1）。 2599402) 发现于女性。此外，性别也呈现出不同的结果。在女性中，最显着的SNP聚集在6号染色体上。然而，除了6号染色体外，在男性中，也可以在3号染色体上发现显着的HBV感染SNP。我们进一步研究了 FUMA 中的基因功能，以确定男性和女性之间反应组前 Notch 表达和加工的差异。我们发现 POGLUT1 和 HIST1H2BC 仅出现在男性中，而不出现在女性中。根据我们的研究，与女性相比，包括 POGLUT1 和 HIST1H2BC 在内的反应组 Pre-Notch 表达与台湾男性患乙型肝炎的风险相关。© 2024。作者。

Hepatitis B, a liver infection caused by the hepatitis B virus (HBV), can develop into a chronic infection that puts patients at high risk of death from cirrhosis and liver cancer. In this study, we aimed to investigate the difference of reactome pre-Notch expression and processing between males and females by using gene to function analysis in FUMA.We analyzed Taiwan Biobank (TWB) data pertaining to 48,874 women and 23,178 men individuals which were collected from 2008 to 2019. According to hepatitis B surface antigen (HBsAg) status in hematology, positive and negative were classified into case and control in the genome-wide association study (GWAS) analysis.We found 4715 women and 2656 men HBV cases. The genomic risk loci were different between males and females. In male, three risk loci (rs3732421, rs1884575 and Affx-28516147) were detected while eight risk loci (Affx-4564106, rs932745, rs7574865, rs34050244, rs77041685, rs107822, rs2296651 and rs12599402) were found in female. In addition, sex also presented different results. In females, the most significant SNPs are gathered in chromosome 6. However, except for chromosome 6, significant HBV infection SNPs also could be found in chromosome 3 among males. We further investigated gene function in FUMA to identify the difference in reactome pre-Notch expression and processing between males and females. We found that POGLUT1 and HIST1H2BC only appeared in men but not in women.According to our study, the reactome pre-Notch expression including POGLUT1 and HIST1H2BC was associated with a risk of Hepatitis B in Taiwanese men when compared to women.© 2024. The Author(s).