我们的目的是前瞻性评估糖尿病风险降低饮食 (DRRD) 评分与肝癌发生风险和慢性肝病特异性死亡率之间的关联。我们纳入了来自妇女健康倡议观察性研究和常规饮食组的 98,786 名绝经后女性饮食调整试验的结果。 DRRD 评分由八个因素得出：膳食纤维、咖啡、坚果、多不饱和脂肪酸的高摄入量、红肉和加工肉的低摄入量、高血糖指数食物、含糖饮料 (SSB) 和反式脂肪在基线（1993-1998）进行的经过验证的食物频率调查问卷。使用 Cox 比例风险回归模型估算肝癌发病率和慢性肝病死亡率的多变量风险比 (HR) 和 95% 置信区间 (CI)。经过中位随访 22.0 年，发现了 216 例肝癌病例和 153 例慢性肝病病例。已证实肝病死亡。较高的 DRRD 评分与患肝癌的风险降低（HRTertile 3 与 Tertile 1 = 0.69；95% CI：0.49-0.97；Ptrend = 0.03）和慢性肝病死亡率（HRT3 与 T1 = 0.54；Ptrend = 0.03）显着相关。 95% CI：0.35-0.82；P 趋势 = 0.003）。我们进一步发现与膳食纤维和咖啡呈负相关，与膳食血糖指数、SSB 和反式脂肪呈正相关。较高的 DRRD 评分与绝经后女性患肝癌和慢性肝病死亡率的降低相关。© 2024 内科杂志出版协会。

We aimed to prospectively evaluate the association between a diabetes risk reduction diet (DRRD) score and the risk of liver cancer development and chronic liver disease-specific mortality.We included 98,786 postmenopausal women from the Women's Health Initiative-Observational Study and the usual diet arm of the Diet Modification trial. The DRRD score was derived from eight factors: high intakes of dietary fiber, coffee, nuts, polyunsaturated fatty acids, low intakes of red and processed meat, foods with high glycemic index, sugar-sweetened beverages (SSBs), and trans fat based on a validated Food-Frequency Questionnaire administered at baseline (1993-1998). Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for liver cancer incidence and chronic liver disease mortality were estimated using Cox proportional hazards regression models.After a median follow-up of 22.0 years, 216 incident liver cancer cases and 153 chronic liver disease deaths were confirmed. A higher DRRD score was significantly associated with a reduced risk of developing liver cancer (HRTertile 3 vs. Tertile 1 = 0.69; 95% CI: 0.49-0.97; Ptrend = 0.03) and chronic liver disease mortality (HRT3 vs. T1 = 0.54; 95% CI: 0.35-0.82; Ptrend = 0.003). We further found inverse associations with dietary fiber and coffee, and positive associations with dietary glycemic index, SSBs, and trans fat. A higher DRRD score was associated with reduced risk of developing liver cancer and chronic liver disease mortality among postmenopausal women.© 2024 The Association for the Publication of the Journal of Internal Medicine.