透明质酸及其化学衍生物在稳态、癌症及组织再生中的免疫作用
Role of Hyaluronic acid and its chemical derivatives in immunity during homeostasis, cancer and tissue regeneration
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影响因子:9.2
分区:医学1区 Top / 病理学1区 免疫学2区
发表日期:2024 Sep 06
作者:
Paolo Rosales, Daiana Vitale, Antonella Icardi, Ina Sevic, Laura Alaniz
DOI:
10.1007/s00281-024-01024-7
摘要
在过去几十年中，科学家已认识到细胞外基质（ECM）中各种组分在维持稳态免疫中的关键作用。此外，这些组分的合成或降解水平的失调直接影响肿瘤过程引起的组织损伤或组织再生中的免疫反应机制。ECM是由蛋白质、蛋白多糖和糖胺聚糖（GAGs）组成的复杂网络。透明质酸（HA）是该网络中的主要GAG之一，其代谢受到严格生理调控，在损伤过程中迅速变化，影响从干细胞到免疫细胞的不同细胞行为。在本综述中，我们讨论了天然或化学修饰的HA如何与其特异性受体相互作用，并调节免疫细胞的细胞内外通信，重点关注癌症和组织再生条件下的作用。
Abstract
Over the last few decades, scientists have recognized the critical role that various components of the extracellular matrix (ECM) play in maintaining homeostatic immunity. Besides, dysregulation in the synthesis or degradation levels of these components directly impacts the mechanisms of immune response during tissue injury caused by tumor processes or the regeneration of the tissue itself in the event of damage. ECM is a complex network of protein compounds, proteoglycans and glycosaminoglycans (GAGs). Hyaluronic acid (HA) is one of the major GAGs of this network, whose metabolism is strictly physiologically regulated and quickly altered in injury processes, affecting the behavior of different cells, from stem cells to differentiated immune cells. In this revision we discuss how the native or chemically modified HA interacts with its specific receptors and modulates intra and intercellular communication of immune cells, focusing on cancer and tissue regeneration conditions.