透明质酸及其化学衍生物在稳态，癌症和组织再生过程中的免疫力中的作用
Role of Hyaluronic acid and its chemical derivatives in immunity during homeostasis, cancer and tissue regeneration
影响因子:9.20000
分区:医学1区 Top / 病理学1区 免疫学2区
发表日期:2024 Sep 06
作者:
Paolo Rosales, Daiana Vitale, Antonella Icardi, Ina Sevic, Laura Alaniz
摘要
在过去的几十年中，科学家认识到细胞外基质（ECM）的各个组成部分在维持稳态免疫中发挥的关键作用。此外，这些成分的合成或降解水平的失调直接影响由肿瘤过程引起的组织损伤或组织本身在损伤时组织本身再生的机制。 ECM是一个复杂的蛋白质化合物，蛋白聚糖和糖胺聚糖（GAGS）的网络。透明质酸（HA）是该网络的主要堵嘴之一，该网络的代谢受到严格的生理调节，并在损伤过程中迅速改变，影响了不同细胞的行为，从干细胞到分化的免疫细胞。在此修订中，我们讨论了天然或化学修饰的HA如何与其特定受体相互作用，并调节免疫细胞的内部和细胞间通信，重点是癌症和组织再生条件。
Abstract
Over the last few decades, scientists have recognized the critical role that various components of the extracellular matrix (ECM) play in maintaining homeostatic immunity. Besides, dysregulation in the synthesis or degradation levels of these components directly impacts the mechanisms of immune response during tissue injury caused by tumor processes or the regeneration of the tissue itself in the event of damage. ECM is a complex network of protein compounds, proteoglycans and glycosaminoglycans (GAGs). Hyaluronic acid (HA) is one of the major GAGs of this network, whose metabolism is strictly physiologically regulated and quickly altered in injury processes, affecting the behavior of different cells, from stem cells to differentiated immune cells. In this revision we discuss how the native or chemically modified HA interacts with its specific receptors and modulates intra and intercellular communication of immune cells, focusing on cancer and tissue regeneration conditions.