术前血浆纤维蛋白原水平是乳腺癌手术后妇女长期存活的危险因素
Preoperative plasma fibrinogen level is a risk factor for the long-term survival of postmenopausal women after surgery for breast cancer
影响因子:3.60000
分区:医学2区 / 妇产科学2区 老年医学3区
发表日期:2024 Nov
作者:
Jinxi Hu, Dong Xu, Hanqian Zeng, Yijun Chen, Xiaoli Zhu
摘要
研究表明，纤维蛋白原水平与乳腺癌患者的预后之间存在关联。然而，由于月经周期，纤维蛋白原水平明显易受波动。这项研究探讨了术前血浆纤维蛋白原水平与手术后绝经后乳腺癌妇女的预后之间的关系。855例绝经后乳腺癌患者监测了10年。 COX比例危害回归模型用于执行单变量和多变量分析，以识别具有实质性预后价值的因素。中位随访时间为77个月（51-105个月），最长为142个月。在随访期间，记录了65例死亡（7.6％）。多变量COX回归结果表明，术前血浆纤维蛋白原水平（危险比[HR] = 1.615，95％置信区间[CI]：1.233-2.115）和年龄（HR = 1.626，95％CI：1.250-2.116）是10年的总体乳腺癌症，而均为10年的危险因素，而均为10年的总体生存。 （HR = 0.414，95％CI：0.202-0.846）是一个独立的保护因素。多元COX回归结果还显示，术前血浆纤维蛋白原水平是10年无病生存的独立危险因素（HR = 1.398，95％CI：1.137-1.719）和10年远距离转移的无转移生存期（HR = 1.436，95％CI：1.15％CI：1.153-1.7887）。手术治疗后绝经后乳腺癌患者的长期预后较差。
Abstract
Studies have indicated an association between fibrinogen levels and the prognosis of breast cancer patients. However, fibrinogen levels are notably susceptible to fluctuations due to the menstrual cycle. This study explored the relationship between preoperative plasma fibrinogen levels and the prognosis of postmenopausal breast cancer women after surgery.855 patients with postmenopausal breast cancer were monitored for 10 years. Cox proportional hazards regression models were used to perform univariate and multivariate analyses to identify factors that are of substantial prognostic value.The median follow-up was 77 months (51-105 months), and the maximum 142 months. Over the follow-up period, 65 deaths (7.6 %) were recorded. Multivariate Cox regression results show that preoperative plasma fibrinogen level (hazard ratio [HR] =1.615, 95 % confidence interval [CI]: 1.233-2.115) and age (HR = 1.626, 95%CI: 1.250-2.116) were independent risk factors for 10-year overall survival after surgery in postmenopausal breast cancer patients, while endocrine therapy (HR = 0.414, 95%CI: 0.202-0.846) was an independent protective factor. Multivariate Cox regression results also show preoperative plasma fibrinogen level was an independent risk factor for 10-year disease-free survival (HR = 1.398, 95 % CI: 1.137-1.719) and 10-year distant metastasis-free survival (HR = 1.436, 95%CI: 1.153-1.787).Elevated pretreatment plasma fibrinogen levels are associated with a poorer long-term prognosis in postmenopausal breast cancer patients following surgical treatment.