铁死亡是一种非凋亡形式的细胞死亡，其特征是铁依赖性和脂质过氧化。铁死亡涉及一系列病理过程，例如癌症。许多研究已证实铁死亡在抑制癌细胞增殖中发挥着重要作用。此外，还开发了一系列小分子化合物，包括erastin、RSL3和FIN56，可用作铁死亡诱导剂。铁死亡诱导剂与抗癌药物的联合治疗可以在癌症治疗中产生显着的协同效应，并且接受这些联合治疗的患者比接受传统治疗的患者表现出更好的预后。因此，深入了解铁死亡在癌症中的作用对于癌症的治疗具有重要意义。该综述主要阐述了铁死亡的分子生物学特征和机制，总结了铁死亡在癌症发生和治疗中的作用，阐述了铁死亡在患者预后预测和药物发现中的应用，并讨论了靶向铁死亡的前景。© 2024 Published by Elsevier B.V. 代表沉阳药科大学。

Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation. Ferroptosis is involved in a range of pathological processes, such as cancer. Many studies have confirmed that ferroptosis plays an essential role in inhibiting cancer cell proliferation. In addition, a series of small-molecule compounds have been developed, including erastin, RSL3, and FIN56, which can be used as ferroptosis inducers. The combination of ferroptosis inducers with anticancer drugs can produce a significant synergistic effect in cancer treatment, and patients treated with these combinations exhibit a better prognosis than patients receiving traditional therapy. Therefore, a thorough understanding of the roles of ferroptosis in cancer is of great significance for the treatment of cancer. This review mainly elaborates the molecular biological characteristics and mechanism of ferroptosis, summarizes the function of ferroptosis in cancer development and treatment,illustrates the application of ferroptosis in patient's prognosis prediction and drug discovery, and discusses the prospects of targeting ferroptosis.© 2024 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University.