没有冠状动脉疾病 (CAD) 的糖尿病 (DM) 患者的全因死亡率高于既没有 DM 也没有 CAD 的患者。我们检查了患有和不患有 CAD 的 DM 患者的具体死因。我们对 2003 年至 2016 年间在丹麦西部接受 CAG 的所有患者进行了一项队列研究。使用丹麦健康登记处，对患者进行最长 10 年的随访，并根据情况进行分层其 DM 和 CAD 状态。结果包括全因死亡、癌症死亡、循环死亡和内分泌死亡。计算了十年累积风险以及调整和未调整的风险比（aHR 和 HR）。总共纳入了 132,432 名患者（28,524 例死亡，中位随访时间为 6.2 年）。与既没有 DM 也没有 CAD 的患者相比，没有 CAD 的 DM 患者的 10 年全因死亡风险更高（27.9% vs 19.7%，aHR 1.43 [95% CI 1.35-1.52]）、癌症死亡风险（7.2% vs 1.35-1.52）。 5.4%，aHR 1.29 [95% CI 1.15-1.46]）、循环性死亡（9.1% vs 6.9%，aHR 1.35 [95% CI 1.22-1.49]）和内分泌死亡（3.9% vs 0.3%，aHR 14.02 [95] % CI 10.95-17.95]）。在内分泌死亡中，无 CAD 的 DM 患者中，87% 是由于 DM 的典型并发症，如糖尿病肾病和酮症酸中毒。无 CAD 的糖尿病患者表现出更高的全因死亡率风险，这主要是由于癌症、循环系统疾病的发病率升高和内分泌死亡，特别是与糖尿病微血管并发症相关的死亡。© 2024 Birindwa 等人。

Diabetes mellitus (DM) patients without coronary artery disease (CAD) have a higher all-cause mortality rate than patients with neither DM nor CAD. We examined cause-specific death of DM patients with and without CAD.We conducted a cohort study of all patients who underwent CAG in Western Denmark between 2003 and 2016. Using Danish health registries, patients were followed for a maximum of 10 years and stratified according to their DM and CAD status. Outcomes included all-cause-, cancer-, circulatory-, and endocrinologic death. Ten-year cumulative risks were computed as well as adjusted and unadjusted hazard ratios (aHR and HR).A total of 132,432 patients (28,524 deaths, median follow-up of 6.2 years) were included. Compared to patients with neither DM nor CAD, DM patients without CAD had a higher 10-year risk of all-cause death (27.9% versus 19.7%, aHR 1.43 [95% CI 1.35-1.52]), cancer death (7.2% versus 5.4%, aHR 1.29 [95% CI 1.15-1.46]), circulatory death (9.1% versus 6.9%, aHR 1.35 [95% CI 1.22-1.49]), and endocrinologic death (3.9% versus 0.3%, aHR 14.02 [95% CI 10.95-17.95]). Among endocrinologic deaths, 87% were due to classical complications of DM, such as diabetic nephropathy and ketoacidosis, in DM patients without CAD.Diabetes patients without CAD exhibit a higher risk of all-cause mortality, driven primarily by elevated rates of cancer, circulatory, and endocrinologic deaths, particularly related to diabetic microvascular complications.© 2024 Birindwa et al.