塞内加尔海鲷（Diplodus bellottii, Steindachner 1882）中诊断出的异位甲状腺腺瘤：迈向准确诊断的探索
Ectopic thyroid adenoma diagnosed in a Senegal seabream (Diplodus bellottii, Steindachner 1882): Towards an accurate diagnosis
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影响因子:2.2
分区:农林科学3区 / 渔业3区 海洋与淡水生物学3区 兽医学3区
发表日期:2024 Dec
作者:
Gabriela Fernandes da Silva, Fátima Faria, Fátima Gil, Nuno Leitão, Paulo Ribeiro, Katia Pinello, João Niza-Ribeiro, Irina Amorim
DOI:
10.1111/jfd.14015
摘要
软骨鱼的甲状腺组织主要位于咽部区域，通常会扩展到邻近的解剖位置。本文报道一只塞内加尔海鲷（Diplodus bellottii）左鳃盖区域的结节性病变经手术切除后进行显微镜检查。显微镜观察显示，病变边界不规则，由柱状上皮细胞组成，排列成管状乳头状结构，围绕一个中央腔隙，腔内充满无细胞、嗜酸性均质材料（“胶质”）。为了确定病变的组织发生学来源，采用免疫组化技术，使用AE1/AE3、CK7、甲状腺球蛋白和明胶蛋白抗体进行检测。肿瘤细胞表现出低有丝分裂指数，CK7和甲状腺球蛋白免疫染色阳性。因此，诊断为异位甲状腺腺瘤。本文描述了经典用于哺乳动物的抗体在鱼类甲状腺疾病诊断中的成功应用。鱼类甲状腺组织的增生可能反映环境与生理失衡，因此对这些肿瘤的研究和正确诊断在该物种中尤为重要。
Abstract
Thyroid tissue in teleosts is located mainly in the pharyngeal region, usually reaching other adjacent anatomical locations. Herein, a nodular lesion located in the left operculum of a Senegal seabream (Diplodus bellottii) was surgically excised and sent for microscopical evaluation. Microscopically, the lesion presented irregular borders and consisted in columnar epithelial cells arranged in a tubulopapillary pattern, surrounding a central lumen filled with acellular, acidophilic and homogeneous, material ('colloid'). To determine the lesion's histogenesis, immunohistochemistry was performed employing antibodies for AE1/AE3, CK7, thyroglobulin and vimentin. The neoplastic cells presented low mitotic index and positive immunolabelling for CK7 and thyroglobulin. Therefore, a diagnosis of ectopic thyroid adenoma was made. Herein, the successful employment of antibodies classically used in mammals for accurate diagnosis of thyroid disorders is described. Proliferation of thyroid tissue in fish may reflect environmental and physiological imbalances, making the study and correct diagnosis of these tumours in this species important.