在塞内加尔Seabream中诊断出的异位甲状腺腺瘤（Evellodus Bellottii，Steindachner 1882）：迈向准确的诊断
Ectopic thyroid adenoma diagnosed in a Senegal seabream (Diplodus bellottii, Steindachner 1882): Towards an accurate diagnosis
影响因子:2.20000
分区:农林科学3区 / 渔业3区 海洋与淡水生物学3区 兽医学3区
发表日期:2024 Dec
作者:
Gabriela Fernandes da Silva, Fátima Faria, Fátima Gil, Nuno Leitão, Paulo Ribeiro, Katia Pinello, João Niza-Ribeiro, Irina Amorim
摘要
硬骨植物中的甲状腺组织主要位于咽部区域，通常达到其他相邻的解剖位置。在此，通过手术切除了塞内加尔Seabream（Everlodus bellottii）左孔的结节病变，并进行了微观评估。从显微镜上讲，病变呈现不规则的边界，由柱状上皮细胞组成，该细胞以微管乳头模式排列，周围围绕着充满千细胞，嗜酸和均匀的材料的中央腔（“胶体”）。为了确定病变的组织发生，对AE1/AE3，CK7，甲状腺球蛋白和波形蛋白的抗体进行了免疫组织化学。肿瘤细胞对CK7和甲状腺球蛋白的有丝分裂指数和阳性免疫标记表现出低。因此，对异位甲状腺腺瘤进行了诊断。在此，描述了经典用于准确诊断甲状腺疾病的抗体的成功使用。鱼类中甲状腺组织的增殖可能反映了环境和生理失衡，从而使研究并正确诊断了对该物种中这些肿瘤的诊断。
Abstract
Thyroid tissue in teleosts is located mainly in the pharyngeal region, usually reaching other adjacent anatomical locations. Herein, a nodular lesion located in the left operculum of a Senegal seabream (Diplodus bellottii) was surgically excised and sent for microscopical evaluation. Microscopically, the lesion presented irregular borders and consisted in columnar epithelial cells arranged in a tubulopapillary pattern, surrounding a central lumen filled with acellular, acidophilic and homogeneous, material ('colloid'). To determine the lesion's histogenesis, immunohistochemistry was performed employing antibodies for AE1/AE3, CK7, thyroglobulin and vimentin. The neoplastic cells presented low mitotic index and positive immunolabelling for CK7 and thyroglobulin. Therefore, a diagnosis of ectopic thyroid adenoma was made. Herein, the successful employment of antibodies classically used in mammals for accurate diagnosis of thyroid disorders is described. Proliferation of thyroid tissue in fish may reflect environmental and physiological imbalances, making the study and correct diagnosis of these tumours in this species important.