胃肠道肿瘤是亚洲癌症负担的重要组成部分。本研究旨在利用 2021 年全球疾病负担研究 (GBD 2021) 的数据评估 1990 年至 2021 年亚洲胃肠道肿瘤的负担。 6 的绝对发病率、死亡率和伤残调整生命年 (DALY) 数和比率提取亚洲48个国家的胃肠道肿瘤（结直肠癌（CRC）、胃癌（SC）、胰腺癌（PC）、食道癌（EC）、肝癌（LC）和胆囊胆道癌（GBTC））来自 GBD 2021。根据性别、年龄、年份、地点和社会人口指数 (SDI) 分析差异。2021 年，SC 是亚洲疾病负担最高的疾病 (DALYs=1641 万 [95% UI: 13.70, 19.62] ]）。 1990年至2021年，亚洲EC、LC和SC的年龄标化发病率下降，而CRC和PC的发病率显着上升，其中CRC上升幅度最大（AAPC=1.08 [95% CI: 1.02 to 1.12]）。胃肠道肿瘤 DALY 率在 70 岁及以上达到峰值，男性通常高于女性。此外，与亚洲其他次区域相比，东亚承受着更高的负担。较高的 SDI 与 PC 的 DALY 率增加相关，但其他胃肠道肿瘤没有观察到线性关系。亚洲胃肠道肿瘤的负担仍然很高，并可能继续增加。因此，有效的预防和治疗措施对于应对胃肠道肿瘤带来的挑战至关重要。© 2024 Jiang et al.

Gastrointestinal tumors represent a significant component of the cancer burden in Asia. This study aims to evaluate the burden of gastrointestinal tumors in Asia from 1990 to 2021 using data from the Global Burden of Disease Study 2021 (GBD 2021).The absolute incidence, mortality, and disability adjusted life years (DALYs) number and rate of six gastrointestinal tumors(colon and rectum cancer (CRC), stomach cancer (SC), pancreatic cancer (PC), esophageal cancer (EC), liver cancer (LC) and gallbladder and biliary tract cancer (GBTC)) in 48 Asian countries were extracted from GBD 2021. Differences were analyzed based on gender, age, year, location and socio-demographic index (SDI).In 2021, SC accounted for the highest disease burden in Asia (DALYs=16.41million [95% UI: 13.70, 19.62]). From 1990 to 2021, the age-standardized incidence rates of EC, LC, and SC in Asia declined, while the incidence rates of CRC and PC increased significantly, with CRC showing the largest rise (AAPC=1.08 [95% CI: 1.02 to 1.12]). Gastrointestinal tumors DALY rates peaked at age 70 and above, with males generally exhibiting higher rates than females. Furthermore, East Asia bears a higher burden compared to other Asian subregions. A higher SDI correlates with increased DALY rates for PC, but no linear relationship was observed for other gastrointestinal tumors.The burden of gastrointestinal tumors in Asia remains high and may continue to increase. Therefore, effective prevention and treatment measures are essential to address the challenge posed by gastrointestinal tumors.© 2024 Jiang et al.