越来越多的证据表明，肠道微生物组在包括癌症在内的许多病理状况中发挥着关键作用。事实上，肠道和大脑之间发生的双向通讯（称为“肠脑轴”）最近与脑肿瘤病理学有关。在这里，我们重点关注当前支持肠道微生物组与脑肿瘤联系的研究，重点关注高级别神经胶质瘤（所有脑肿瘤中最具侵袭性的一种），以及对神经胶质瘤肿瘤微环境的影响。我们讨论了肠脑轴信号的潜在用途，以改善对当前和未来治疗方法的反应。我们强调，新型治疗策略的成功可能依赖于患者特定的微生物组特征，个性化治疗方法应考虑这些特征。版权所有 © 2024。由 Elsevier Ltd 出版。

Increasing evidence suggests that the gut microbiome plays a key role in a host of pathological conditions, including cancer. Indeed, the bidirectional communication that occurs between the gut and the brain, known as the 'gut-brain axis,' has recently been implicated in brain tumour pathology. Here, we focus on current research that supports a gut microbiome-brain tumour link with emphasis on high-grade gliomas, the most aggressive of all brain tumours, and the impact on the glioma tumour microenvironment. We discuss the potential use of gut-brain axis signals to improve responses to current and future therapeutic approaches. We highlight that the success of novel treatment strategies may rely on patient-specific microbiome profiles, and these should be considered for personalised treatment approaches.Copyright © 2024. Published by Elsevier Ltd.