我们很快就了解了非淋巴组织中 T 淋巴细胞（组织驻留记忆 T (TRM) 细胞）的存在和功能。适应性免疫的中心支柱已经从经典的中央记忆T细胞（在再感染时产生后代）和效应记忆细胞在血液中循环并巡逻组织扩展到包括驻留在实体器官和组织内并迁移的TRM细胞。它们的发育和维持已被详细研究，为它们用于对抗感染的独特特性如何有益于实体瘤的治疗提供了令人兴奋的线索。我们概述了 CD8 TRM 细胞以及使它们对疫苗接种和癌症治疗感兴趣的特性。© 2024 Wiley periodicals LLC。

We have rapidly gained insights into the presence and function of T lymphocytes in non-lymphoid tissues, the tissue-resident memory T (TRM) cells. The central pillar of adaptive immunity has been expanded from classic central memory T cells giving rise to progeny upon reinfection and effector memory cells circulating through the blood and patrolling the tissues to include TRM cells that reside and migrate inside solid organs and tissues. Their development and maintenance have been studied in detail, providing exciting clues on how their unique properties used to fight infections may benefit therapies against solid tumors. We provide an overview of CD8 TRM cells and the properties that make them of interest for vaccination and cancer therapies.© 2024 Wiley Periodicals LLC.