结直肠癌的手术治疗存在静脉血栓栓塞 (VTE) 的风险。我们调查了接受开放式细胞减灭术联合热腹腔化疗（CRS  HIPEC）治疗结直肠癌腹膜转移的患者和接受微创手术（MIS）治疗局限性直肠癌的患者30天内凝血和纤溶的变化以及VTE发生率。 该队列研究包括 45 名 CRS  HIPEC 患者和 45 名 MIS 患者。术前、手术结束时以及术后第 1 天、第 3 至 4 天和第 5 至 7 天采集血样。在 POD 3 至 7 天内对 VTE 进行系统超声筛查。如果出现并发症，则进行计算机断层扫描。怀疑。主要终点是从术前到手术结束期间凝血酶原片段 1  2 (F1  2) 水平的平均变化 (Δ) 与 [95% 置信区间] 的差异。次要终点是凝血和纤溶生物标志物从术前到 POD 5 至 7 的平均变化以及 VTE 发生率的差异。 从术前到手术结束，两组的 F1  2 水平均升高。从术前到手术结束，CRS HIPEC 患者的 F1  2 水平平均增幅显着高于 MIS 患者：Δ1,322 [1,040:1,604] pmol/L，p< 0.01。 CRS  HIPEC 后 VTE 发生率显着高于 MIS（24% vs. 5%，p = 0.01）。 两次手术后 F1  2 水平均升高，但在 CRS  HIPEC 后升高程度要高得多。接受CRS  HIPEC治疗的患者30天内VTE发生率显着高于MIS患者。Thieme。版权所有。

 Surgical treatment of colorectal cancer carries a risk for venous thromboembolism (VTE). We investigated changes in coagulation and fibrinolysis and the VTE incidence within 30 days in patients undergoing open cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) for peritoneal metastases from colorectal cancer and minimally invasive surgery (MIS) for localized rectal cancer. This cohort study included 45 CRS + HIPEC and 45 MIS patients. Blood samples were obtained preoperatively, at the end of surgery, and postoperative day (POD) 1, 3 to 4, and 5 to 7. Systematic ultrasonographic screening for VTE was performed between POD 3 and 7. Computed tomography scan was performed if complications were suspected. The primary endpoint was the difference in mean change (Δ) with [95% confidence intervals] from preoperative to end of surgery in prothrombin fragment 1 + 2 (F1 + 2) levels. Secondary endpoints were the difference in mean change in biomarkers of coagulation and fibrinolysis from preoperative to POD 5 to 7 and the VTE incidence. F1 + 2 levels increased from preoperative to the end of surgery in both groups. The mean increase from preoperative to end of surgery in F1 + 2 levels was significantly greater in CRS + HIPEC patients than MIS patients: Δ1,322 [1,040:1,604] pmol/L, p < 0.01. The VTE incidence was significantly higher after CRS + HIPEC than MIS (24 vs. 5%, p = 0.01). F1 + 2 levels were increased after both procedures, but to a far greater extent following CRS + HIPEC. The VTE incidence within 30 days was significantly higher in patients treated with CRS + HIPEC than in MIS patients.Thieme. All rights reserved.