趋化因子及其受体是趋化细胞因子家族，在健康和疾病的免疫反应中具有重要功能。当发现它们还与肿瘤微环境中早期和晚期炎症阶段的控制有关时，它们已知的生理作用（例如白细胞运输的调节和免疫器官的发育）引起了极大的兴趣。事实上，在乳腺癌中，趋化因子合成和/或其受体表达的不平衡被认为参与了疾病进展的调节，包括侵袭和转移。该领域的研究进展迅速，基于趋化因子和趋化因子受体拮抗剂的新药物的开发正在成为有吸引力的替代策略。本章简要介绍了趋化因子及其受体在调节乳腺癌进展方面的不同功能。版权所有 © 2024。由 Elsevier Inc. 出版。

Chemokines and their receptors are a family of chemotactic cytokines with important functions in the immune response in both health and disease. Their known physiological roles such as the regulation of leukocyte trafficking and the development of immune organs generated great interest when it was found that they were also related to the control of early and late inflammatory stages in the tumor microenvironment. In fact, in breast cancer, an imbalance in the synthesis of chemokines and/or in the expression of their receptors was attributed to be involved in the regulation of disease progression, including invasion and metastasis. Research in this area is progressing rapidly and the development of new agents based on chemokine and chemokine receptor antagonists are emerging as attractive alternative strategies. This chapter provides a snapshot of the different functions reported for chemokines and their receptors with respect to the potential to regulate breast cancer progression.Copyright © 2024. Published by Elsevier Inc.