半胱胺(CA)在啮齿类动物中诱导十二指肠溃疡(Selye and Szabo, Nature 244:458-459, 1973)。半胱氨酸(Cys)是形成CA的前体(通过辅酶A的分解代谢)，不会引起十二指肠损伤(Szabo等人，J Pharmacol Exp Ther 223：68-76，1982)。 CA 还具有抗突变和抗癌药理学（Fujisawa 等人，PLoS ONE 7, 2012；Lee, Adv Pharmacol Pharm Sci 2023:2419444, 2023）。我们提出了一种 CA 诱导的细胞死亡依赖于氧气和 CA 双加氧酶 (ADO) 的机制，该机制可以解释 50 年来的谜团：为什么 CA 会导致溃疡，而 Cys 不会。这些表达辅酶 A 分解酶的细胞会遭受一种独特类型的氧和酶结合 Fe2 依赖性死亡，即 II 型铁死亡。© 2024。作者获得 Springer Nature Switzerland AG 的独家许可。

Cysteamine (CA) induces duodenal ulcers in rodents (Selye and Szabo, Nature 244:458-459, 1973). Cysteine (Cys), a precursor for the formation of CA (via catabolism of coenzyme A), does not cause lesions in the duodenum (Szabo et al., J Pharmacol Exp Ther 223:68-76, 1982). CA also has antimutagenic and anticancer pharmacology (Fujisawa et al., PLoS ONE 7, 2012; Lee, Adv Pharmacol Pharm Sci 2023:2419444, 2023). We propose a mechanism of CA-induced cell death dependent on oxygen and CA dioxygenase (ADO) that can explain the 50-year-old mystery as to why CA is, but Cys is not, ulcerogenic. Those cells expressing coenzyme A-catabolizing enzymes are subject to a unique type of oxygen- and enzyme-bound-Fe2+-dependent death, type II ferroptosis.© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.