高丽红参提取物（KRGE）（科：五加科）是亚洲使用最广泛的传统草药之一。多项研究表明KRGE具有抗炎、抗疲劳、抗肥胖、抗氧化、抗癌作用。将Sprague-Dawley大鼠分为PTU诱导的甲状腺功能减退症五组和LT4诱导的甲状腺功能减退症六组甲状腺功能亢进症。实验结束时，处死大鼠，收集血液、甲状腺和肝脏样本。每周记录体重，并使用酶联免疫测定法评估血清激素水平。甲状腺和肝组织用苏木精和伊红染色。 KRGE在0.5% CMC中配制，给药前保存在4°C。在LT4诱导的甲亢模型中，与PTU组相比，KRGE阻止了体重、甲状腺重量、肝脏重量、血糖和甲状腺激素水平的下降。它还降低了 LT4 治疗后 T3、T4 和血清天冬氨酸转氨酶水平的增加。此外，KRGE 改善了甲状腺和肝脏组织病理学，这是 PTU 诱导的甲状腺功能减退模型中未观察到的效果。综合考虑，我们的研究指出，KRGE 通过降低甲状腺激素的产生，对 LT4 引起的大鼠甲状腺功能亢进症具有潜在的保护作用。© 2024 韩国研究所东方医学。由 Elsevier B.V. 出版

Korean red ginseng extract (KRGE) (Family: Araliaceae) is one of the most widely used traditional herbs in Asia. Multiple studies have shown that KRGE has anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects.Sprague-Dawley rats were divided into five groups for PTU-induced hypothyroidism and six groups for LT4-induced hyperthyroidism. At the experiment's conclusion, rats were sacrificed, and blood, thyroid gland, and liver samples were collected. Body weight was recorded weekly, and serum hormone levels were assessed using enzyme-linked immunoassay. Thyroid gland and liver tissues were stained with hematoxylin and eosin. KRGE was prepared in 0.5% CMC and stored at 4 °C before administration.In the LT4-induced hyperthyroidism model, KRGE prevented decreases in body weight, thyroid gland weight, liver weight, serum glucose, and thyroid hormone levels compared to the PTU group. It also reduced increases in T3, T4, and serum aspartate aminotransferase levels after LT4 treatment. Additionally, KRGE improved thyroid gland and liver histopathology, effects not observed in the PTU-induced hypothyroidism model.All things considered, our research points to KRGE's potential protective role in rat hyperthyroidism caused by LT4 by lowering thyroid hormone production.© 2024 Korea Institute of Oriental Medicine. Published by Elsevier B.V.