铜是一种重要的微量营养素，在许多生物环境中发挥重要功能。其代谢紊乱与肿瘤的发生和癌症的治疗干预有关，这强调了保持铜稳态的至关重要性。铜中毒是一种由铜调节的调节性细胞死亡（RCD），铜浓度升高时会被激活，促使人们对其在肿瘤发生中的影响进行研究。在这篇综述中，对细胞内的铜动力学和稳态维持进行了探索。此外，它还深入研究了铜凋亡的机制及其与癌症相关信号通路的相互作用。讨论了铜死亡和铁死亡之间的潜在协同作用及其对肿瘤免疫调节的影响。此外，解决癌症铜凋亡的有希望的途径包括评估铜螯合剂和离子载体的效用。通过解决有关铜凋亡的紧迫问题并概述其在癌症发病机制和治疗中的关键作用，本综述提出将铜凋亡作为抗肿瘤治疗的一个有前途的前沿领域，可能会彻底改变癌症治疗策略。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Copper, a vital micronutrient, performs essential functions in numerous biological settings. Its disrupted metabolism is implicated in both the initiation of tumors and therapeutic interventions for cancer, underscoring the critical necessity of preserving copper homeostasis. Cuproptosis, a regulated cell death (RCD) modulated by copper, is activated in response to elevated copper concentrations, prompting an investigation into its implication in oncogenesis. Within this review, an exploration is conducted into copper dynamics and homeostasis maintenance within cells. Furthermore, it delves into the mechanisms underlying cuproptosis and its interplay with signaling pathways implicated in cancer. The potential synergy between cuproptosis and ferroptosis and its impact on tumor immunomodulation is discussed. Additionally, promising avenues for addressing cuproptosis in cancer involve assessing the utility of copper chelators and ionophores. By addressing pressing questions surrounding cuproptosis and outlining its pivotal role in cancer pathogenesis and treatment, this review propounds targeting cuproptosis as a promising frontier in antitumor therapy, potentially revolutionizing cancer treatment strategies.Copyright © 2024 Elsevier B.V. All rights reserved.