放射疗法后的射精功能：系统评价和荟萃分析
Ejaculatory function after radiotherapy for prostate cancer: a systematic review and meta-analysis
影响因子:5.80000
发表日期:2024 Sep 14
作者:
Umar Ghaffar, Behzad Abbasi, Kevin D Li, Nikit Venishetty, Nizar Hakam, Adrian Fernandez, Robert Pearce, Hiren V Patel, Marvin N Carlisle, Benjamin N Breyer
摘要
关于前列腺辐射对射精功能的影响的数据很少。我们进行了系统的综述和荟萃分析，以评估前列腺辐射后男性的射精结果。我们查询PubMed，Embase和Web of Science，以识别17篇评估射辐射后射精功能的文章。主要结果是动态率，次要结果包括射精体积（EV），射精不适以及射精功能得分（EFS）的平均下降。我们通过纽卡斯尔 - 奥塔瓦量表评估了学习质量。我们使用反方差和随机效应模型计算了合并比例。我们确定了17个观察性研究，有2156名患者报告射精后的射精轮廓。七项研究利用了外部束放射疗法，7种近距离放射治疗，1个立体定向RT和2次使用外部或近距离放射治疗。十项研究报道了动脉汇聚率。竞争性动脉肿瘤，EV降低和EJD的汇总比例为18％（95％CI，11-36％），85％（95％CI，81-89％）和24％（95％CI，16-35％）。五项研究报道了EFS放射后的EFS下降。接受辐射治疗的患者可能会在射精发生重大变化，例如缺乏射精，减少EV和EJD。重要的是要向他们咨询这些潜在的副作用。
Abstract
Scant data exists on the impacts of prostate radiation on ejaculatory function. We performed a systematic review and meta-analysis to assess ejaculatory outcomes in men after prostate radiation.We queried PubMed, Embase, and Web of Science to identify 17 articles assessing ejaculatory function post-radiation. The primary outcome was anejaculation rate and secondary outcomes included ejaculatory volume (EV), ejaculatory discomfort, and mean decline in ejaculatory function scores (EFS). We assessed study quality with the Newcastle-Ottawa scale. We calculated pooled proportions using inverse variance and random effects models.We identified 17 observational studies with 2156 patients reporting ejaculatory profiles post-radiation. Seven studies utilized external beam radiation therapy, 7 brachytherapy, 1 stereotactic RT and 2 utilized either external or brachytherapy. Ten studies reported an anejaculation rate. Pooled proportion of patients having anejaculation, decreased EV and EjD were 18% (95% CI, 11-36%), 85% (95% CI, 81-89%) and 24% (95% CI, 16-35%), respectively. Five studies reported decline in EFS post-radiation.Patients receiving radiation treatment may experience significant changes in their ejaculation, such as the absence of ejaculation, reduced EV, and EjD. It is important to counsel them about these potential side effects.