前列腺癌放射治疗后的射精功能:系统评价和荟萃分析。
Ejaculatory function after radiotherapy for prostate cancer: a systematic review and meta-analysis.
发表日期:2024 Sep 14
作者:
Umar Ghaffar, Behzad Abbasi, Kevin D Li, Nikit Venishetty, Nizar Hakam, Adrian Fernandez, Robert Pearce, Hiren V Patel, Marvin N Carlisle, Benjamin N Breyer
来源:
PROSTATE CANCER AND PROSTATIC DISEASES
摘要:
关于前列腺辐射对射精功能影响的数据很少。我们进行了系统回顾和荟萃分析,以评估前列腺放射后男性的射精结果。我们查询了 PubMed、Embase 和 Web of Science,找到了 17 篇评估放射后射精功能的文章。主要结局是射精率,次要结局包括射精量(EV)、射精不适和射精功能评分(EFS)平均下降。我们使用纽卡斯尔-渥太华量表评估研究质量。我们使用逆方差和随机效应模型计算了汇总比例。我们确定了 17 项观察性研究,涉及 2156 名报告放射后射精情况的患者。 7 项研究采用外照射放射治疗,7 项研究采用近距离放射治疗,1 项研究采用立体定向放疗,2 项研究采用外照射或近距离放射治疗。十项研究报告了射精率。不射精、EV 和 EjD 降低的患者比例分别为 18% (95% CI, 11-36%)、85% (95% CI, 81-89%) 和 24% (95% CI, 16-35%) , 分别。五项研究报告了放射后 EFS 下降。接受放射治疗的患者的射精可能会发生显着变化,例如不射精、EV 减少和 EjD。向他们提供关于这些潜在副作用的咨询非常重要。© 2024。作者,获得 Springer Nature Limited 的独家许可。
Scant data exists on the impacts of prostate radiation on ejaculatory function. We performed a systematic review and meta-analysis to assess ejaculatory outcomes in men after prostate radiation.We queried PubMed, Embase, and Web of Science to identify 17 articles assessing ejaculatory function post-radiation. The primary outcome was anejaculation rate and secondary outcomes included ejaculatory volume (EV), ejaculatory discomfort, and mean decline in ejaculatory function scores (EFS). We assessed study quality with the Newcastle-Ottawa scale. We calculated pooled proportions using inverse variance and random effects models.We identified 17 observational studies with 2156 patients reporting ejaculatory profiles post-radiation. Seven studies utilized external beam radiation therapy, 7 brachytherapy, 1 stereotactic RT and 2 utilized either external or brachytherapy. Ten studies reported an anejaculation rate. Pooled proportion of patients having anejaculation, decreased EV and EjD were 18% (95% CI, 11-36%), 85% (95% CI, 81-89%) and 24% (95% CI, 16-35%), respectively. Five studies reported decline in EFS post-radiation.Patients receiving radiation treatment may experience significant changes in their ejaculation, such as the absence of ejaculation, reduced EV, and EjD. It is important to counsel them about these potential side effects.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.