黑色素瘤是最具侵袭性和致命性的皮肤癌，由黑色素细胞（皮肤色素产生细胞）的转化引起。到 2024 年，美国将新诊断出约 10,000 例黑色素瘤病例，并有约 8,000 人死于黑色素瘤。在这项研究中，我们用 G 蛋白偶联雌激素受体激动剂 LNS8801 治疗一组自发发展为转移性黑色素瘤 (TGS) 的雄性和雌性转基因小鼠，以评估对疾病进展的功效。第二组雄性和雌性 TGS 小鼠也接受 UVB 照射，以模拟暴露在阳光下。在为期 32 周的实验过程中，小动物成像 IVIS 系统拍摄可见图像来跟踪肿瘤进展，并收集血液和组织样本进行分子分析。结果表明，LNS8801 的功效存在性别偏见，并且 LNS8801 对雄性和雌性 TGS 小鼠均具有紫外线防护作用。© 2024 作者。色素细胞

Melanoma is the most aggressive and deadly form of skin cancer that arises from the transformation of melanocytes, the pigment producing cells of the skin. In the year 2024 there will be approximately 10,000 new cases of melanoma diagnosed and approximately 8,000 deaths attributed to melanoma in the United States. In this study we treated a group of male and female transgenic mice that spontaneously develop metastatic melanoma, TGS, with a G-protein-coupled estrogen receptor agonist LNS8801 to assess the efficacy on disease progression. A second group of male and female TGS mice was also exposed to UVB irradiation to mimic exposure to sunlight. Over the course of the 32-week experiment, visible images were taken by the small animal imaging IVIS system to track tumor progression, and blood and tissue samples were collected for molecular analyses. Results showed that sex-biased effects were observed in the efficacy of LNS8801 and that LNS8801 shows a UV-protective influence in both male and female TGS mice.© 2024 The Author(s). Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.