骨转移仍然是一个临床挑战，并且仍然被认为是无法治愈的。虽然基于纳米颗粒的药物递送和光热疗法（PTT）在治疗皮下实体瘤方面显示出良好的前景，但由于骨转移部位的难以接近和骨转移的复杂性，它们在治疗骨转移方面的治疗效果有限。在此，我们报道了一种由热敏脂质体（TSL）和金纳米棒（GNR）组成的简单纳米平台，通过改进的化疗结合GNR辅助的PTT来治疗骨转移。 TSL的脂质组合首先被定制以调节其在生理条件下的稳定性以及其对PTT引起的温和热疗的敏感性。然后将获得的负载药物的 TSL 与 GNR 结合，通过简单的孵化形成纳米平台。细胞实验表明，在近红外（NIR）照射下，纳米平台通过PTT、PTT触发的热敏药物释放以及PTT增强肿瘤细胞对药物的敏感性，有效抑制肿瘤细胞的活力和迁移能力。在骨转移的小鼠模型中，纳米平台能够有效地将负载的药物和 GNR 递送到骨转移部位，以便在局部近红外照射下快速释放药物。通过杀死肿瘤细胞并重新平衡破骨细胞和成骨细胞的更新，纳米平台在很大程度上保留了骨骼结构，以缓解疼痛和延长生存时间。受纳米平台获取和治疗操作简单性的启发，基于脂质体的热敏药物递送与 GNR 辅助 PTT 相结合的策略被认为在治疗骨转移方面非常有前景。© 2024 作者。

Bone metastasis remains a clinical challenge and is still considered incurable. While nanoparticles-based drug delivery and photothermal therapy (PTT) show promise in treating subcutaneous solid tumor, their therapeutic outcome in treating bone metastasis is limited, due to the inaccessibility of bone metastatic site and the complexity of bone metastasis. Herein, we reported a simple nanoplatform composed of thermo-sensitive liposomes (TSL) and gold nanorods (GNR) to treat bone metastasis through improved chemotherapy combined with GNR-assisted PTT. Lipid combination of TSL was firstly tailored to regulate its stability under physiological condition as well as its sensitivity in responding to PTT-caused mild hyperthermia. The obtained TSL with loaded drug was then combined with GNR to form the nanoplatform through unsophisticated incubation. Cell experiments revealed that upon near-infrared (NIR) irradiation, the nanoplatform effectively inhibited the viability and migration ability of tumor cells through PTT, PTT-triggered thermo-sensitive drug release, and PTT-augmented sensitivity of tumor cells to drug. In a murine model of bone metastasis, the nanoplatform enabled effective delivery of loaded drug and GNR to bone metastatic site for rapid drug release upon local NIR irradiation. Through killing tumor cells and rebalancing the turnover of osteoclasts and osteoblasts, the nanoplatform largely preserved bone structure for pain relief and survival extension. Inspired by the simplicity of nanoplatform acquirement and treatment operation, the strategy of liposomes-based thermo-sensitive drug delivery in combination with GNR-assisted PTT is considered greatly promising in treating bone metastasis.© 2024 The Authors.