目前，由于缺乏有效药物，围手术期肺部感染等肺部并发症仍然是导致肺损伤患者长期住院和死亡的主要原因。 Clusterzyme是一种具有高酶样活性和安全性的人工酶，在减少氧化应激和免疫调节方面表现出良好的效果。在这里，我们展示了在肺气道上施用并通过簇酶拯救受损器官的功能化贴片。该贴片的长期抗氧化能力显着改善脂多糖引起的肺功能损伤，显着减少肺杯状细胞化生和氧化应激。细胞因子白细胞介素-1β、白细胞介素-6和肿瘤坏死因子-α等炎症因子水平下降50%，而线粒体DNA拷贝数增加50%，ATP产量增加100%。小鼠肺功能显着改善，表明该贴片可以通过调节氧化应激和免疫反应以及保护线粒体来挽救肺损伤，为有效干预肺损伤提供了途径。

Currently, pulmonary complications such as lung infections during the perioperative period are still the main cause of prolonged hospitalization and death in patients with lung injury due to the lack of effective drugs. Clusterzyme, a kind of artificial enzyme with a high enzyme-like activity and safety profile, exhibits good effects on reducing oxidative stress and immunomodulation. Here, we present the functionalized patches that is administered on the lung airways and rescues the injured organ via clusterzymes. The long-term antioxidant capacity of the patches significantly ameliorated lipopolysaccharide-induced lung function impairment with a significant reduction in lung goblet cell metaplasia and oxidative stress. The inflammatory factors such as cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α levels decreased by 50%, while the mtDNA copy number increased by 50% and ATP production increased by 100%. Mice lung function was significantly improved, suggesting that the patches can rescue lung injury by modulating oxidative stress and immune responses as well as protecting the mitochondria, providing an avenue for effective intervention of lung injury.