较小的份量可能有助于减少人群的饮酒量，从而降低患 7 种癌症和其他疾病的风险。据我们所知，当前的研究首次评估了从啤酒中去除最大的生啤酒份量（1 英品脱）对啤酒、啤酒和苹果酒销售（以下为方便起见，简称为“啤酒销售”）的影响。该研究于 2023 年 2 月至 5 月期间在英格兰 13 个获得许可的场所进行。它采用 A-B-A 反转设计，设置 3 个连续的 4 周周期，其中“A”代表提供标准份量的非干预期，“B”代表提供最大份量生啤酒（1 英制）的干预期。品脱（568 毫升））从现有系列中删除，因此可用的最大尺寸为三分之二品脱。如果没有提供三分之二品脱的服务，干预措施包括引入该服务量并同时取消该品脱的服务量。主要结果是从电子销售数据中提取的所有啤酒的平均每日销售量，包括生啤酒、瓶装啤酒和罐装啤酒（以毫升为单位）。次要结果是平均每日葡萄酒销量（毫升）和每日收入（英镑）。 13 个场所完成了这项研究，其中 12 个场所按照方案完成了这项研究，并纳入了初步分析。调整预先指定的协变量后，干预导致平均每日变化为 -2,769 ml (95% CI [-4,188, -1,578] p < 0.001) 或 -9.7% (95% CI [-13.5%, -6.1%]干预期间，每日销售的啤酒量增加了 232 毫升（95% CI [13, 487]，p = 0.035）或 7.2%（95% CI [0.4%，14.5%]）。下降了 5.0%（95% CI [9.6%，-0.3%]，p = 0.038）。考虑到这种干预措施可能会减少啤酒的销量，取消生啤酒的最大份量（英制品脱）会减少啤酒的销量。酒精消费，值得在酒精控制政策中考虑。ISRCTN.com ISRCTN18365249。版权所有：© 2024 Mantzari 等人。这是根据知识共享署名许可条款分发的开放获取文章，允许无限制使用、分发和复制在任何媒体上，只要注明原作者和来源。

Smaller serving sizes could contribute towards reducing alcohol consumption across populations and thereby decrease the risk of 7 cancers and other diseases. To our knowledge, the current study is the first to assess the impact on beer, lager, and cider sales (hereafter, for ease, referred to just as "beer sales") of removing the largest draught serving size (1 imperial pint) from the options available in licensed premises under real-word conditions.The study was conducted between February and May 2023, in 13 licensed premises in England. It used an A-B-A reversal design, set over 3 consecutive 4-weekly periods with "A" representing the nonintervention periods during which standard serving sizes were served, and "B" representing the intervention period when the largest serving size of draught beer (1 imperial pint (568 ml)) was removed from existing ranges so that the largest size available was two-thirds of a pint. Where two-third pints were not served, the intervention included introducing this serving size in conjunction with removing the pint serving size. The primary outcome was the mean daily volume of all beer sold, including draught, bottles, and cans (in ml), extracted from electronic sales data. Secondary outcomes were mean daily volume of wine sold (ml) and daily revenue (£). Thirteen premises completed the study, 12 of which did so per protocol and were included in the primary analysis. After adjusting for prespecified covariates, the intervention resulted in a mean daily change of -2,769 ml (95% CI [-4,188, -1,578] p < 0.001) or -9.7% (95% CI [-13.5%, -6.1%] in beer sold. The daily volume of wine sold increased during the intervention period by 232 ml (95% CI [13, 487], p = 0.035) or 7.2% (95% CI [0.4%, 14.5%]). Daily revenues decreased by 5.0% (95% CI [9.6%, -0.3%], p = 0.038).Removing the largest serving size (the imperial pint) for draught beer reduced the volume of beer sold. Given the potential of this intervention to reduce alcohol consumption, it merits consideration in alcohol control policies.ISRCTN.com ISRCTN18365249.Copyright: © 2024 Mantzari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.