越来越多的证据凸显了肿瘤微环境（TME）中肿瘤内皮细胞（TEC）对于促进肿瘤生长和逃避免疫反应的重要性。免疫调节内皮细胞 (IMEC) 代表了 EC 的独特塑料表型，在健康和疾病中发挥调节免疫力的能力。这篇综述讨论了我们目前对癌症生物学中 IMEC 的理解，仔细研究了单细胞报告的见解，以比较它们在不同肿瘤类型、病症和物种中的特征和功能动态。我们研究了在癌症治疗中利用 IMEC 的可能影响，特别是检查它们对现有疗法疗效的影响以及利用它们作为优化免疫治疗策略目标的潜力。版权所有 © 2024。由 Elsevier Inc. 出版。

Growing evidence highlights the importance of tumor endothelial cells (TECs) in the tumor microenvironment (TME) for promoting tumor growth and evading immune responses. Immunomodulatory endothelial cells (IMECs) represent a distinct plastic phenotype of ECs that exerts the ability to modulate immunity in health and disease. This review discusses our current understanding of IMECs in cancer biology, scrutinizing insights from single-cell reports to compare their characteristics and function dynamics across diverse tumor types, conditions, and species. We investigate possible implications of exploiting IMECs in the context of cancer treatment, particularly examining their influence on the efficacy of existing therapies and the potential to leverage them as targets in optimizing immunotherapeutic strategies.Copyright © 2024. Published by Elsevier Inc.