丹麦基于人群的家族性癫痫和儿童癌症研究。
Danish population based study of familial epilepsy and childhood cancer.
发表日期：2024 Sep
作者：
Corbin C Platamone, Chuanjie Deng, Rajarshi Mazumder, Beate Ritz, Jorn Olsen, Johnni Hansen, Chai Saechao, Julia E Heck
来源：
EUROPEAN JOURNAL OF EPIDEMIOLOGY
摘要：
调查孕产妇或儿童癫痫、妊娠期使用抗惊厥药物和儿童癌症之间关系的研究结果不一致，有时甚至是矛盾的。通过连接丹麦国家数据库，我们获得了癫痫和儿童癌症的诊断以及抗惊厥药物的使用数据。我们使用条件逻辑回归估计了所有或特定儿童癌症与孕产妇或儿童癫痫和抗惊厥治疗相关的调整后优势比。母亲癫痫与后代的所有儿童期癌症呈正相关，特别是与急性淋巴细胞白血病（比值比 (OR) = 1.68，95% 置信区间 (CI) = 1.16, 2.43）和肾母细胞瘤 (OR = 2.13，95% CI) = 0.97, 4.68)。当考虑母亲曾经（一生）摄入抗惊厥药物时，发现与所有癌症（OR = 1.14，95% CI = 1.00, 1.30）和中枢神经系统肿瘤（CNS）（OR = 1.36，95% CI = 1.04, 1.76) 以及后代中的神经母细胞瘤 (OR = 1.76, 95% CI = 1.06, 2.90)。妊娠前或妊娠期间母亲使用抗惊厥药物与后代中枢神经系统肿瘤相关（OR = 1.99，95% CI = 0.99，4.00）。© 2024。Springer Nature B.V.
Results from studies investigating the association between maternal or child epilepsy, use of anticonvulsants in pregnancy, and childhood cancer are inconsistent and at times contradictory. Linking Danish national databases, we obtained epilepsy and childhood cancer diagnoses, and anticonvulsant use data. We estimated adjusted odds ratios of all or specific childhood cancers in relation to maternal or child epilepsy and anticonvulsant therapies using conditional logistic regression. Maternal epilepsy was positively associated with all childhood cancers in offspring, specifically, with acute lymphoblastic leukemia (Odds Ratio (OR) = 1.68, 95% Confidence Interval (CI) = 1.16, 2.43) and Wilms tumor (OR = 2.13, 95% CI = 0.97, 4.68). When considering maternal ever (lifetime) ingestion of anticonvulsants, a positive association was found with all cancers (OR = 1.14, 95% CI = 1.00, 1.30), and central nervous system tumors (CNS) (OR = 1.36, 95% CI = 1.04, 1.76) as well as neuroblastoma (OR = 1.76, 95% CI = 1.06, 2.90) among offspring. Maternal anticonvulsant use before or during the index pregnancy was related to CNS tumors in offspring (OR = 1.99, 95% CI = 0.99, 4.00).© 2024. Springer Nature B.V.