常见泌尿系统疾病，包括良性前列腺增生 (BPH)、尿路感染 (UTI)、尿石症、膀胱癌、肾癌和前列腺癌，在地理和特定区域内都有所不同。对泌尿系统疾病的全球负担进行全面、准确的评估至关重要。我们按年龄、性别、地点、 2021 年全球疾病负担 (GBD) 的年份和年份。我们根据社会人口指数 (SDI) 和可归因的风险因素分析了与泌尿系统疾病相关的负担。使用估计年度百分比变化 (EAPC) 和 95% 置信区间 (CI) 来评估随时间变化的负担趋势。2021 年，BPH 和 UTI 是年龄标准化发病率 (ASIR) 和年龄标准化发病率的主要原因患病率（ASPR），分别为每10万人5531.88和2782.59。前列腺癌是年龄标准化死亡率（ASMR）和年龄标准化伤残调整生命年率（ASDR）的主要原因，发病率分别为每10万人12.63和217.83。 1990年至2021年，UTI的ASIR、ASPR、ASMR和ASDR呈上升趋势，而尿石症则呈下降趋势。中、中低 SDI 五分位数水平显示出与 UTI、尿石症和 BPH 相关的较高发病率、患病率、死亡率和 DALY，而高和中高 SDI 五分位数水平则显示这三种癌症的发病率较高。这六种泌尿系统疾病的负担表现出不同的年龄和性别分布模式。 2021年，高体重指数（BMI）导致全球肾癌死亡人数占20.07%，而吸烟占膀胱癌死亡人数的26.48%和前列腺癌死亡人数的3.00%。 6种泌尿系统疾病的全球负担给公众带来了重大负担健康挑战。迫切的国际合作对于促进泌尿系统疾病管理的改善至关重要，包括开发有效的诊断筛查工具和实施高质量的预防和治疗策略。© 2024。作者。

The burden of common urologic diseases, including benign prostatic hyperplasia (BPH), urinary tract infections (UTI), urolithiasis, bladder cancer, kidney cancer, and prostate cancer, varies both geographically and within specific regions. It is essential to conduct a comprehensive and precise assessment of the global burden of urologic diseases.We obtained data on incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for the aforementioned urologic diseases by age, sex, location, and year from the Global Burden of Disease (GBD) 2021. We analyzed the burden associated with urologic diseases based on socio-demographic index (SDI) and attributable risk factors. The trends in burden over time were assessed using estimated annual percentage changes (EAPC) along with a 95% confidence interval (CI).In 2021, BPH and UTI were the leading causes of age-standardized incidence rate (ASIR) and age-standardized prevalence rate (ASPR), with rates of 5531.88 and 2782.59 per 100,000 persons, respectively. Prostate cancer was the leading cause of both age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR), with rates of 12.63 and 217.83 per 100,000 persons, respectively. From 1990 to 2021, there was an upward trend in ASIR, ASPR, ASMR, and ASDR for UTI, while urolithiasis showed a downward trend. The middle and low-middle SDI quintile levels exhibited higher incidence, prevalence, mortality, and DALYs related to UTI, urolithiasis, and BPH, while the high and high-middle SDI quintile levels showed higher rates for the three cancers. The burden of these six urologic diseases displayed diverse age and sex distribution patterns. In 2021, a high body mass index (BMI) contributed to 20.07% of kidney cancer deaths worldwide, while smoking accounted for 26.48% of bladder cancer deaths and 3.00% of prostate cancer deaths.The global burden of 6 urologic diseases presents a significant public health challenge. Urgent international collaboration is essential to advance the improvement of urologic disease management, encompassing the development of effective diagnostic screening tools and the implementation of high-quality prevention and treatment strategies.© 2024. The Author(s).