贝赫切特病对牙龈炎症反应的影响

Behçet's disease modifies the gingival inflammatory response

JOURNAL OF PERIODONTOLOGY

影响因子:3.8

分区:医学2区 Top / 牙科与口腔外科1区

发表日期:2025 Apr

作者: Selin Sahinkaya, Melis Yilmaz, Ekin Yay, Hilal Toygar, Nur Balci, Dursun Dorukhan Altinisik, Zekayi Kutlubay, Alpdogan Kantarci

DOI: 10.1002/JPER.24-0182

摘要

贝赫切特病（BD）发病机制涉及严重后果如失明、中枢神经系统表现及深静脉血栓，影响全身及局部炎症变化。我们假设BD对牙龈健康存在不良影响，并加重牙龈炎的严重程度。研究共纳入37例无牙周炎表现的BD患者牙龈炎病例。对照组包括19例系统健康的牙龈炎患者（G组）和20例既无牙周病又无系统性疾病的健康个体（C组）。BD患者根据对治疗反应被分为稳定组和不稳定组。测量临床牙周参数以评估BD对牙龈健康的影响。采用多重免疫分析检测血清和唾液中的ELA-2（中性粒细胞弹性蛋白酶-2）、SLPI（分泌性白细胞蛋白酶抑制剂）、α1-抗胰蛋白酶（α1-AT）、血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）及肿瘤坏死因子α（TNF-α），以衡量BD的系统性及局部炎症影响。结果显示，BD组的菌斑指数（PI）、探诊窝深度（PPD）及出血征阳性（BOP）明显高于对照（p<0.05）；BD组IL-6在血清和唾液中均高于G组（p<0.05）；BD稳定组唾液中的ELA-2水平高于对照，TNF-α和SLPI也显著高于对照（p<0.05）；而BD组唾液中的α1-抗胰蛋白酶水平显著低于对照。研究表明，BD患者的牙龈炎症反应受损，炎症状态更为严重。

Abstract

Behçet's disease (BD) pathogenesis involves severe outcomes such as blindness, central nervous system manifestations, and deep venous thrombosis that impacts systemic and local inflammatory changes. We tested the hypothesis that BD negatively affects gingival health and increases the severity of gingivitis.The study included 37 BD patients with gingivitis without any sign of periodontitis. Systemically healthy 19 patients with gingivitis (G) and 20 periodontally and systemically healthy individuals (C) were recruited as controls. BD patients were further grouped as stable and unstable based on their responses to BD treatment. Clinical periodontal parameters were measured to determine the impact of BD on gingival health. Serum and saliva levels of ELA-2 (neutrophil elastase-2), SLPI (secretory leukocyte protease inhibitor), α1-AT (alpha1-anti-trypsin), VEGF (vascular endothelial growth factor), IL-6 (interleukin-6), IL-8 (interleukin-8), and TNF-α (tumor necrosis factor alpha) were analyzed using multiplex immunoassay to measure the systemic and local inflammatory impact of BD.Plaque index (PI), probing pocket depth (PPD), and bleeding on probing (BOP) were significantly higher in the BD group than in the controls (p < 0.05). IL-6 was higher in both serum and saliva in the BD group than in the G group (p < 0.05). ELA-2 levels in saliva were higher in the stable BD group than in the controls, while TNF-α and SLPI were statistically significantly higher in BD than in the control (p < 0.05). Salivary α1-AT level was statistically lower in the BD group compared to the control group.Our study suggested that the gingival inflammatory profile was impaired in patients with BD.