白塞氏病 (BD) 发病机制涉及严重的后果，例如失明、中枢神经系统表现以及影响全身和局部炎症变化的深静脉血栓形成。我们检验了 BD 对牙龈健康产生负面影响并增加牙龈炎严重程度的假设。该研究纳入了 37 名患有牙龈炎但没有任何牙周炎迹象的 BD 患者。招募 19 名全身健康的牙龈炎患者 (G) 和 20 名牙周和全身健康的个体 (C) 作为对照。根据 BD 患者对 BD 治疗的反应，将其进一步分为稳定型和不稳定型。测量临床牙周参数以确定 BD 对牙龈健康的影响。血清和唾液中 ELA-2（中性粒细胞弹性蛋白酶-2）、SLPI（分泌性白细胞蛋白酶抑制剂）、α1-AT（α1-抗胰蛋白酶）、VEGF（血管内皮生长因子）、IL-6（白介素-6）的水平使用多重免疫测定法对 、IL-8（白细胞介素 8）和 TNF-α（肿瘤坏死因子 α）进行分析，以测量 BD 的全身和局部炎症影响。斑块指数 (PI)、探查袋深度 (PPD) 和BD 组探诊出血 (BOP) 显着高于对照组 (p < 0.05)。 BD 组血清和唾液中的 IL-6 均高于 G 组 (p < 0.05)。稳定 BD 组唾液中的 ELA-2 水平高于对照组，而 BD 组的 TNF-α 和 SLPI 显着高于对照组（p < 0.05）。与对照组相比，BD 组的唾液 α1-AT 水平在统计学上较低。我们的研究表明 BD 患者的牙龈炎症状况受损。© 2024 美国牙周病学会。

Behçet's disease (BD) pathogenesis involves severe outcomes such as blindness, central nervous system manifestations, and deep venous thrombosis that impacts systemic and local inflammatory changes. We tested the hypothesis that BD negatively affects gingival health and increases the severity of gingivitis.The study included 37 BD patients with gingivitis without any sign of periodontitis. Systemically healthy 19 patients with gingivitis (G) and 20 periodontally and systemically healthy individuals (C) were recruited as controls. BD patients were further grouped as stable and unstable based on their responses to BD treatment. Clinical periodontal parameters were measured to determine the impact of BD on gingival health. Serum and saliva levels of ELA-2 (neutrophil elastase-2), SLPI (secretory leukocyte protease inhibitor), α1-AT (alpha1-anti-trypsin), VEGF (vascular endothelial growth factor), IL-6 (interleukin-6), IL-8 (interleukin-8), and TNF-α (tumor necrosis factor alpha) were analyzed using multiplex immunoassay to measure the systemic and local inflammatory impact of BD.Plaque index (PI), probing pocket depth (PPD), and bleeding on probing (BOP) were significantly higher in the BD group than in the controls (p < 0.05). IL-6 was higher in both serum and saliva in the BD group than in the G group (p < 0.05). ELA-2 levels in saliva were higher in the stable BD group than in the controls, while TNF-α and SLPI were statistically significantly higher in BD than in the control (p < 0.05). Salivary α1-AT level was statistically lower in the BD group compared to the control group.Our study suggested that the gingival inflammatory profile was impaired in patients with BD.© 2024 American Academy of Periodontology.