本研究旨在评估和比较高强度和低强度呼气肌力量训练（EMST）对疾病严重程度、全身炎症、氧化应激、呼吸肌力量、运动能力、症状、日间嗜睡、疲劳严重程度和睡眠质量的影响这项双盲、随机、平行研究纳入了 31 名被诊断为中度 OSAS 的男性患者。患者被随机分为两组：高 EMST 组和低 EMST 组。 EMST 在家使用，每周 7 天，每天一次，持续 25 次呼吸，共 12 周。使用口压装置测量呼吸肌力量。疾病严重程度 (Apne Hipopne 指数-AHI) 和多导睡眠图呼吸睡眠事件、总氧化剂水平 (TOS)、总抗氧化剂水平 (TAS)、氧化应激指数 (OSI)、C 反应蛋白 (CRP)、肿瘤坏死因子 -评估血清中的α（TNF-α）、白细胞介素6（IL-6）和白细胞介素10（IL-10）水平。高EMST组的AHI变化百分比（50.8％）显着更高高于低 EMST 组 (6.3%) (p=0.002, d=1.31)。总体而言，MEP每增加1个单位，AHI下降0.149点（b=-0.149；CR=-3.065；p=0.002），AHI每增加1个单位，ODI增加0.746点（b=0.746；CR） =10.604；p<0.001)。两组中 TOS、OSI、TNF-α 和 IL-6 水平下降速度相似。EMST 显着降低全身炎症和氧化应激，同时改善中度 OSAS 男性患者的呼气肌力量。高 EMST 比低 EMST 在增强疾病严重程度方面更有效。 EMST 是一种实用、有效且有前景的中度 OSAS 患者肺康复治疗方法。© 作者 2024。由牛津大学出版社代表睡眠研究协会出版。版权所有。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息，请联系journals.permissions@oup.com。

This study aimed to evaluate and compare the effects of high and low-intensity expiratory muscle strength training (EMST) on disease severity, systemic inflammation, oxidative stress, respiratory muscle strength, exercise capacity, symptoms, daytime sleepiness, fatigue severity, and sleep quality in male patients with obstructive sleep apnea syndrome (OSAS).Thirty-one male patients diagnosed with moderate OSAS were included in this double-blind, randomized, parallel study. Patients were randomized into two groups: High-EMST and Low-EMST groups. EMST was used at home 7 days/week, once a day, for 25 breaths, 12 weeks. Respiratory muscle strength was measured using a mouth pressure device. Disease severity (Apne Hipopne Index-AHI) and, respiratory sleep events by polysomnography, total oxidant level(TOS), total antioxidant level(TAS), oxidative stress index (OSI), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels by blood serum were evaluated.The percentage of AHI change in the High-EMST group(50.8%) was significantly higher than in the Low-EMST group(6.3%) (p=0.002, d=1.31). In general, as MEP increased by one unit, AHI decreased by 0.149 points (b=-0.149; CR=-3.065; p=0.002), and as AHI increased by one unit, ODI increased by 0.746 points (b=0.746; CR=10.604; p<0.001). TOS, OSI, TNF-α and IL-6 levels decreased at similar rates in both groups.EMST significantly reduces systemic inflammation and oxidative stress while improving expiratory muscle strength in male patients with moderate OSAS. High-EMST is more effective in enhancing the severity of disease than Low-EMST. EMST is a practical, effective, and promising treatment for pulmonary rehabilitation in patients with moderate OSAS.© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.