一氧化碳 (CO) 中毒会导致大脑、心脏和肾脏损伤。我们的目的是确定既往患有一氧化碳中毒的患者的全因死亡风险和特定原因死亡风险之间的关联。这项基于人群的队列研究使用了来自国家健康保险服务数据库和韩国国家死亡登记处的数据。包括 2002 年至 2020 年间诊断为一氧化碳中毒的成年患者和对照组。考虑到年龄、性别、保险类型、收入水平、居住地点、吸烟状况、饮酒情况、肥胖状况、医疗和精神疾病史以及索引日期的查尔森合并症指数，患者与对照组按 1:1 的比例进行匹配。该队列从 2002 年至 2022 年或直至死亡或移民的全因死亡率和特定原因死亡率进行了监测。无。总共包括 48,600 名一氧化碳中毒患者和匹配的对照患者。该队列包括 41.30% 的女性，平均年龄为 48.05 岁。与对照组相比，一氧化碳中毒患者的全因死亡风险显着升高，调整后的风险比 (aHR) 为 15.67 (95% CI, 12.58-19.51)。死亡率与感染（aHR，6.71；95% CI，1.51-29.72）、肿瘤/肿瘤（aHR，5.20；95% CI，3.39-7.99）、内分泌（aHR，13.44；95% CI，1.76-102.70）相关、神经系统（aHR，7.42；95% CI，2.91-18.90）、心血管系统（aHR，8.97；95% CI，5.05-15.93）、呼吸系统（aHR，17.54；95% CI，5.48-56.17）和胃肠道系统（aHR，17.54；95% CI，5.48-56.17） ，24.72；95% CI，3.34-182.69）前者的疾病明显更大。一氧化碳中毒组因包括自杀在内的外部原因导致的死亡显着较高（aHR，50.07；95% CI，30.98-80.90）。与匹配的对照组相比，一氧化碳中毒患者的全因死亡风险更高。此外，各组之间的特定原因死亡风险也不同。版权所有 © 2024，重症监护医学协会和 Wolters Kluwer Health, Inc. 保留所有权利。

Carbon monoxide (CO) poisoning can cause brain, heart, and kidney injuries. We aimed to determine the association of risks of all-cause and cause-specific mortality in patients with previous CO poisoning.This population-based cohort study used data from the National Health Insurance Service database and the National Death Registry of Korea. Adult patients diagnosed with CO poisoning and controls between 2002 and 2020 were included. Patients were matched with controls on a 1:1 ratio, considering age, sex, insurance type, income level, residential location, smoking status, alcohol consumption, obesity status, medical and psychiatric illness history, and Charlson Comorbidity Index at the index date. The cohort was monitored from 2002 to 2022 or until death or emigration in terms of all-cause and cause-specific mortality.None.A total of 48,600 patients with CO poisoning and matched controls were included. The cohort included 41.30% females, and the mean age was 48.05 years. Patients with CO poisoning exhibited a substantially elevated risk of all-cause mortality compared with those in the control group, with an adjusted hazard ratio (aHR) of 15.67 (95% CI, 12.58-19.51). The mortality associated with infectious (aHR, 6.71; 95% CI, 1.51-29.72), neoplasm/oncologic (aHR, 5.20; 95% CI, 3.39-7.99), endocrine (aHR, 13.44; 95% CI, 1.76-102.70), neurologic (aHR, 7.42; 95% CI, 2.91-18.90), cardiovascular (aHR, 8.97; 95% CI, 5.05-15.93), respiratory (aHR, 17.54; 95% CI, 5.48-56.17), and gastrointestinal (aHR, 24.72; 95% CI, 3.34-182.69) disorders was significantly greater in the former. Deaths due to external causes, including suicide, were significantly higher in the CO poisoning group (aHR, 50.07; 95% CI, 30.98-80.90).Patients with CO poisoning exhibited a heightened risk of all-cause mortality compared with the matched controls. Additionally, the cause-specific mortality risk differed between the groups.Copyright © 2024 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.