转移，即恶性细胞从原发肿瘤扩散到继发部位，给癌症治疗带来灾难性负担，并且是癌症患者死亡的主要原因。转移作为癌症进展的主要方面之一，可能会受到病毒感染的强烈影响。事实上，病毒一直是现代癌症研究的核心，并且与大量癌症病例有关。病毒编码元件参与调节与转移的不同阶段有关的基本途径或特定靶标。考虑到新病毒的不断出现及其对癌症进展的贡献，病毒与癌症之间的战争似乎永无休止。在这里，我们的目的是回顾癌症转移所涉及的关键机制和途径，以及病毒机制的影响，以及病毒为了自身利益而操纵这些途径的各种途径。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Metastasis, the dissemination of malignant cells from a primary tumor to secondary sites, poses a catastrophic burden to cancer treatment and is the predominant cause of mortality in cancer patients. Metastasis as one of the main aspects of cancer progression could be strongly under the influence of viral infections. In fact, viruses have been central to modern cancer research and are associated with a great number of cancer cases. Viral-encoded elements are involved in modulating essential pathways or specific targets that are implicated in different stages of metastasis. Considering the continuous emergence of new viruses and the establishment of their contribution to cancer progression, the warfare between viruses and cancer appears to be endless. Here we aimed to review the critical mechanism and pathways involved in cancer metastasis and the influence of viral machinery and various routes that viruses adopt to manipulate those pathways for their benefit.Copyright © 2024 Elsevier B.V. All rights reserved.