层粘连蛋白 (LM) 是形成基底膜 (BM) 所必需的异源三聚体糖蛋白家族。它们充当细胞和细胞外基质 (ECM) 之间的分子桥梁，从而传递影响细胞行为和组织组织的信号。在癌症病理学领域，LM 调节迁移、分化或纤维化等关键过程。这篇综述批判性地研究了 LM 对肿瘤进展的多方面影响，特别关注亚型特异性结构-功能关系，以及这种结构多样性如何影响 BM 的生物力学特性。 LM 与整合素和非整合素细胞表面受体以及其他 ECM 蛋白的相互作用，改变癌细胞对 ECM 硬度的反应，最终影响恶性细胞突破 BM 的能力，这是转移扩散的限制步骤。理解 LM 驱动的肿瘤生物力学的潜在机制有可能更好地理解癌症病理学并设计新的靶向治疗策略。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

Laminins (LMs) constitute a family of heterotrimeric glycoproteins essential for the formation of basement membranes (BM). They act as molecular bridges between cells and the extracellular matrix (ECM), thereby transmitting signals influencing cell behavior and tissue organization. In the realm of cancer pathobiology, LMs regulate key processes such as migration, differentiation, or fibrosis. This review critically examines the multifaceted impact of LMs on tumor progression, with a particular focus on the isoform-specific structure-function relationships, and how this structural diversity contributes to the biomechanical properties of BMs. LM interactions with integrin and non-integrin cell surface receptors, as well as with other ECM proteins, modify the response of cancer cells to the ECM stiffness, ultimately influencing the capacity of malignant cells to breach the BM, a limiting step in metastatic dissemination. Comprehension of the mechanisms underlying LM-driven tumor biomechanics holds potential for better understand cancer pathobiology and design new targeted therapeutic strategies.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.