我们的目的是利用一项健康检查者研究的数据来评估肥胖对韩国中年人死亡率的影响。我们使用了参与者的数据，这些参与者拥有完整的体型信息，并同意将他们的数据与国民死亡联系起来证书数据。 Cox 比例风险模型用于估计全因死亡率、心血管死亡率和癌症死亡率的体重指数 (BMI) 和腰臀比 (WHR) 的风险比 (HR) 和 95% 置信区间 (CI)。该研究共有 115,961 名参与者。结果显示，BMI 与死亡率之间呈 U 形关联，表明 BMI 低于 21 kg/m2 和大于或等于 30 kg/m2 的男性和女性风险均增加。结果显示，BMI 低于 18.5 kg/m² 的男性全因死亡率（调整后 HR：2.24 [95% CI：1.73-2.91]）和心血管死亡率（2.27 [1.23-4.20]）的风险显着较高）。同样，腰臀比小于 0.80 (1.38 [1.08-1.77])、0.90 至小于 0.95 (1.15 [1.02-1.29]) 和大于或等于 0.95 (1.28 [1.11-1.47]) 的男性表现出全因死亡的风险增加。在女性中，体重指数低于 18 公斤/平方米与较高的心血管死亡风险相关 (2.67 [1.13-6.33])。体重过轻与男女死亡风险增加相关，并且死亡风险最低发现于体重指数为 23-25 kg/m2 的轻微超重男性中。

We aimed to assess the impact of obesity on mortality in middle-aged Koreans using data from a Health Examinees study.We used data from the participants who had complete information on body size and gave informed consent for the linkage of their data with the national death certificate data. Cox proportional hazard model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of body mass index (BMI) and waist-to-hip ratio (WHR) for all-cause, cardiovascular, and cancer mortality.A total of 115,961 participants were included in the study. The results showed a U-shaped association between BMI and mortality, indicating that both men and women with BMIs of less than 21 kg/m2 and greater than or equal to 30 kg/m2 are at increased risk. The results showed that men with a BMI of less than 18.5 kg/m² had a significantly higher risk of all-cause mortality (adjusted HR: 2.24 [95% CI: 1.73-2.91]) and cardiovascular mortality (2.27 [1.23-4.20]). Similarly, men with a WHR of less than 0.80 (1.38 [1.08-1.77]), 0.90 to less than 0.95 (1.15 [1.02-1.29]), and greater than or equal to 0.95 (1.28 [1.11-1.47]) showed an increased risk of all-cause mortality. In women, a BMI of less than 18 kg/m² was linked to a higher risk of cardiovascular mortality (2.67 [1.13-6.33]).Being underweight was associated with an increased risk of mortality in both sexes, and the lowest risk of death was found in men who were slightly overweight with a BMI of 23-25 kg/m2.