据推测，牙周炎与许多人类癌症有关。这篇叙述性综述提供了牙周炎与癌症之间关联的当前流行病学证据。使用相关关键词（牙周病、牙周炎、癌症和恶性肿瘤）完成 PubMed 搜索，以识别相关文章。我们对牙周病与一系列癌症之间的关联进行了叙述性综述，包括口腔癌、胃癌和食道癌、结直肠癌、肺癌、胰腺癌、前列腺癌、血液恶性肿瘤、肝癌、乳腺癌和卵巢癌。虽然有大量流行病学证据支持牙周病与癌症之间的关联，但这主要来自队列研究和病例对照研究，因此这种关联可能是间接的，因为很少有治疗试验的证据可以验证牙周病与癌症之间的关系。牙周病在癌症发生和发展过程中的作用。© 2024 John Wiley

There is a postulated association of periodontitis with a number of human cancers. This narrative review provides current epidemiological evidence on the association between periodontitis and cancer. A PubMed search with the relevant keywords (periodontal disease, periodontitis, cancer, and malignancy) was completed to identify relevent articles. We present a narrative review on the association between periodontal disease and a range of cancers, including oral cancer, stomach and esophageal cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, hematological malignancies, liver cancer, breast cancer, and ovarian cancer. While there is a considerable body of epidemiological evidence that supports the association between periodontal disease and cancer, this is largely from cohort and case-control studies and the association may therefore be circumstantial as little evidence exists in the form of treatment trials that would validate the role of periodontal disease in the process of cancer initiation and development.© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.