牙周炎与癌症的流行病学相关性
Epidemiological associations between periodontitis and cancer
DOI 原文链接
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影响因子:15.7
分区:医学1区 Top / 牙科与口腔外科1区
发表日期:2024 Oct
作者:
Jon Higham, Frank A Scannapieco
DOI:
10.1111/prd.12599
摘要
牙周炎与多种人类癌症存在假设性关联。本文综述了关于牙周炎与癌症关系的最新流行病学证据。通过PubMed检索相关关键词（牙周疾病、牙周炎、癌症及恶性肿瘤），筛选出相关文献。我们对牙周疾病与多种癌症（包括口腔癌、胃癌、食管癌、结直肠癌、肺癌、胰腺癌、前列腺癌、血液系统恶性肿瘤、肝癌、乳腺癌和卵巢癌）之间的关系进行了叙述性综述。虽然大量流行病学证据支持牙周疾病与癌症的关联，但这一证据主要来自队列研究和病例对照研究，因此其关联可能具有一定的偶然性，缺乏治疗试验的证据来验证牙周疾病在癌症发生和发展的作用。
Abstract
There is a postulated association of periodontitis with a number of human cancers. This narrative review provides current epidemiological evidence on the association between periodontitis and cancer. A PubMed search with the relevant keywords (periodontal disease, periodontitis, cancer, and malignancy) was completed to identify relevent articles. We present a narrative review on the association between periodontal disease and a range of cancers, including oral cancer, stomach and esophageal cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, hematological malignancies, liver cancer, breast cancer, and ovarian cancer. While there is a considerable body of epidemiological evidence that supports the association between periodontal disease and cancer, this is largely from cohort and case-control studies and the association may therefore be circumstantial as little evidence exists in the form of treatment trials that would validate the role of periodontal disease in the process of cancer initiation and development.