牙周炎与癌症之间的流行病学关联
Epidemiological associations between periodontitis and cancer
影响因子:15.70000
分区:医学1区 Top / 牙科与口腔外科1区
发表日期:2024 Oct
作者:
Jon Higham, Frank A Scannapieco
摘要
假定的牙周炎与许多人类癌症有关。这项叙述性综述提供了有关牙周炎与癌症之间关联的当前流行病学证据。使用相关关键字（牙周疾病，牙周炎，癌症和恶性肿瘤）进行了PubMed搜索以识别相关文章。我们对牙周疾病与包括口腔癌，胃癌和食道癌，大肠癌，肺癌，胰腺癌，前列腺癌，前列腺癌，血液恶性肿瘤，肝癌，乳腺癌，乳腺癌和卵巢癌等疾病的关联进行了叙述性回顾。尽管有大量的流行病学证据支持牙周疾病与癌症之间的关联，但这主要来自队列和病例对照研究，因此，这种关联可能是间接的，因为在治疗试验的形式中很少存在证据，这些证据在癌症开始和发育过程中可以验证周期疾病的作用。
Abstract
There is a postulated association of periodontitis with a number of human cancers. This narrative review provides current epidemiological evidence on the association between periodontitis and cancer. A PubMed search with the relevant keywords (periodontal disease, periodontitis, cancer, and malignancy) was completed to identify relevent articles. We present a narrative review on the association between periodontal disease and a range of cancers, including oral cancer, stomach and esophageal cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, hematological malignancies, liver cancer, breast cancer, and ovarian cancer. While there is a considerable body of epidemiological evidence that supports the association between periodontal disease and cancer, this is largely from cohort and case-control studies and the association may therefore be circumstantial as little evidence exists in the form of treatment trials that would validate the role of periodontal disease in the process of cancer initiation and development.