定量研究长期低剂量体内暴露于铯 137 对 DNA 损伤、致癌性和后代多代的影响。根据下一代小鼠突变率预测人类潜在的遗传风险，以确认当前食品中铯137剂量限制的合理性。在饮用水中向 A/J 小鼠提供铯 137 (100 Bq/mL)，通过 25 代以上的兄弟姐妹交配（G25）促进慢性、低剂量、低剂量率的内部暴露。将 A/J 小鼠与具有相同起源血统的对照品系（不含铯 137 水）进行 DNA 双链断裂 (DSB)、氧化应激、染色体畸变、微核测试结果、全基因组分析、致癌性、肿瘤的比较生长速度和免疫能力。与对照组相比，Cesium-137 组的 DNA DSB 和氧化应激显着增加。然而，在染色体畸变、微核或全基因组序列突变分析方面，各组之间没有观察到显着差异。尽管各组之间的致癌率没有差异，但铯137组的肿瘤生长速度显着受到抑制。 Cesium-137 组的抗肿瘤细胞因子趋势可能促成了这种效应。 G25后，小鼠饮用含有100 Bq/mL Cesium-137的水，其后代没有观察到病理或遗传效应。低剂量率辐射对致癌性的贡献不是累加性的，而是生长抑制性的。尽管负面数据并不是决定性的，但这些发现被认为是高度可靠的。

To quantitatively investigate the effects of chronic low-dose internal exposure to Cesium-137 on DNA damage, carcinogenicity, and offspring over multiple generations. The potential genetic risk in humans was predicted based on next-generation murine mutation rates to confirm the reasonableness of the current Cesium-137 dose limits for food. Cesium-137 (100 Bq/mL) was provided in drinking water to A/J mice, facilitating chronic, low-dose, low-dose-rate internal exposure through sibling mating over 25 generations (G25). The A/J mice were compared with a control strain with the same origin ancestry (no Cesium-137 water) for DNA double-strand breaks (DSBs), oxidative stress, chromosome aberrations, micronucleus test results, whole genome analysis, carcinogenicity, tumor growth rate, and immune competence. Compared to the control group, DNA DSBs and oxidative stress were significantly increased in the Cesium-137 group. However, no significant differences were observed between the groups regarding chromosome aberration, micronuclei, or the whole genome sequence mutation analysis. Although the carcinogenic rate did not differ between the groups, the rate of tumor growth was significantly suppressed in the Cesium-137 group. The anti-tumor cytokine trend in the Cesium-137 group likely contributed to this effect. No pathological or genetic effects were observed in the offspring of mice drinking water containing 100 Bq/mL Cesium-137 after G25. The contribution of low dose-rate radiation to carcinogenicity was not additive but growth-inhibitory. Although the negative data are not conclusive, these findings are deemed highly reliable.