为了使真兽类哺乳动物重要器官的生理过程发挥作用，将核心体温维持在~37°C 恒定非常重要。哺乳动物通过生热作用在体内产生热量。本综述的重点是静息骨骼肌产生的热量，使用与肌肉相同的细胞成分来调节细胞质钙浓度 [Ca2] 和收缩。这一过程被称为基于肌肉的非颤抖产热 (MB-NST)，其关键是由质膜、肌浆网 (SR) 和线粒体协调的微小 Ca2 运动和相关的 ATP 周转。 MB-NST 使具有功能获得性 SR 兰尼碱受体 (RyR) 变体的哺乳动物容易产生过多的热量，这种热量可能致命，称为恶性高热。使用最近开发的技术对 RyR 变体的研究增进了我们对 MB-NST 的理解。

For physiological processes in the vital organs of eutherian mammals to function, it is important to maintain constant core body temperature at ∼37°C. Mammals generate heat internally by thermogenesis. The focus of this review is on heat generated in resting skeletal muscles, using the same cellular components that muscles use to regulate cytoplasmic calcium concentrations [Ca2+] and contraction. Key to this process, known as muscle-based nonshivering thermogenesis (MB-NST), are tiny Ca2+ movements and associated ATP turnover coordinated by the plasma membrane, sarcoplasmic reticulum (SR), and the mitochondria. MB-NST has made mammals with gain-of-function SR ryanodine receptor (RyR) variants vulnerable to excessive heat generation that can be potentially lethal, known as malignant hyperthermia. Studies of RyR variants using recently developed techniques have advanced our understanding of MB-NST.