肝病已成为一个重要的健康问题，其特点是发病率和死亡率高。循环外泌体作为细胞间通讯的重要介质而受到关注，其含有蛋白质和稳定的 mRNA、microRNA 和长非编码 RNA (lncRNA)。这篇综述强调了外泌体lncRNA在各种肝脏疾病的发病机制和诊断中的参与。值得注意的是，外泌体 lncRNA 作为肝癌、肝纤维化和肝病毒感染等疾病的靶标具有治疗潜力。采用在线筛选过程来确定调查外泌体 lncRNA 与各种肝脏疾病之间关联的研究。我们的研究揭示了一系列不同的外泌体携带的lncRNA，包括H19、Linc-ROR、VLDLR、MALAT1、DANCR、HEIH、ENSG00000248932.1、ENST00000457302.2、ZSCAN16-AS1等，与正常肝组织相比，在不同的肝脏疾病中表现出不同的水平。这些外泌体衍生的 lncRNA 越来越被认为是诊断和预测肝脏疾病的关键生物标志物，并得到了新证据的支持。然而，某些外泌体 lncRNA 参与的确切机制仍不完全清楚。此外，使用ENSG00000258332.1、LINC00635和血清AFP对血清外泌体进行联合分析可能作为HCC的新型且有价值的生物标志物。临床上，外泌体ATB表达在HCC中上调，而外泌体HEIH和RP11-513I15.6已显示出区分与HCV感染相关的HCC的潜力。肝脏疾病缺乏可靠的生物标志物，加上外泌体lncRNA和RP11-513I15.6的高特异性和敏感性其非侵入性检测，促进探索其在肝脏疾病诊断、预后和治疗反应的发病机制和生物标志物中的作用。© 2024。亚太肝脏研究协会。

Liver disease has emerged as a significant health concern, characterized by high rates of morbidity and mortality. Circulating exosomes have garnered attention as important mediators of intercellular communication, harboring protein and stable mRNAs, microRNAs, and long non-coding RNAs (lncRNA). This review highlights the involvement of exosomal lncRNA in the pathogenesis and diagnosis of various liver diseases. Notably, exosomal lncRNAs exhibit therapeutic potential as targets for conditions including hepatic carcinoma, hepatic fibrosis, and hepatic viral infections.An online screening process was employed to identify studies investigating the association between exosomal lncRNA and various liver diseases.Our study revealed a diverse array of lncRNAs carried by exosomes, including H19, Linc-ROR, VLDLR, MALAT1, DANCR, HEIH, ENSG00000248932.1, ENST00000457302.2, ZSCAN16-AS1, and others, exhibiting varied levels across different liver diseases compared to normal liver tissue. These exosomal-derived lncRNAs are increasingly recognized as pivotal biomarkers for diagnosing and prognosticating liver diseases, supported by emerging evidence. However, the precise mechanisms underlying the involvement of certain exosomal lncRNAs remain incompletely understood. Furthermore, the combined analysis of serum exosomes using ENSG00000258332.1, LINC00635, and serum AFP may serve as novel and valuable biomarker for HCC. Clinically, exosomal ATB expression is upregulated in HCC, while exosomal HEIH and RP11-513I15.6 have shown potential for distinguishing HCC related to HCV infection.The lack of reliable biomarkers for liver diseases, coupled with the high specificity and sensitivity of exosomal lncRNA and its non-invasive detection, promotes exploring their role in pathogenesis and biomarker for diagnosis, prognosis, and response to treatment liver diseases.© 2024. Asian Pacific Association for the Study of the Liver.