Paeonia属：对活性成分，药理学作用和机制以及临床应用的系统评价
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer
影响因子:7.50000
分区:医学2区 / 药物化学1区 药学1区
发表日期:2024 Sep
作者:
Xinrui Zhou, Aikebaier Alimu, Jiarui Zhao, Xinyi Xu, Xiaowen Li, He Lin, Zhe Lin
摘要
已知Paeonia属植物的主要活性成分具有抗肿瘤活性。已经分离了数百种具有广泛药理活性的化合物，包括单二烯糖苷，类黄酮，单宁，硬霉素，三萜类化合物，类固醇和酚类化合物。其中，单二烯及其糖苷，类黄酮，酚酸和其他成分已被证明对各种癌症具有良好的治疗作用，其主要机制在内，包括诱导凋亡。抑制肿瘤细胞增殖，迁移和侵袭；以及免疫的调节。在这项研究中，许多引用与传统用途有关，植物化学成分，抗肿瘤效应以及Paeonia属的临床应用都从流行且广泛使用的数据库中，例如使用不同的搜索字符串，例如Web of Science，Google Direct，Google Direct，Google Direct，Google Direct，Google Direct和PubMed。对Paeonia属的抗肿瘤成分进行了系统的综述及其对各种癌症的治疗作用，并总结了这些植物化学物质的作用和途径的机理，以提供抗肿瘤研究的进一步基础。
Abstract
The main active constituents of plants of the Paeonia genus are known to have antitumor activity. Hundreds of compounds with a wide range of pharmacological activities, including monoterpene glycosides, flavonoids, tannins, stilbenes, triterpenoids, steroids, and phenolic compounds have been isolated. Among them, monoterpenes and their glycosides, flavonoids, phenolic acids, and other constituents have been shown to have good therapeutic effects on various cancers, with the main mechanisms including the induction of apoptosis; the inhibition of tumor cell proliferation, migration, and invasion; and the modulation of immunity. In this study, many citations related to the traditional uses, phytochemical constituents, antitumor effects, and clinical applications of the Paeonia genus were retrieved from popular and widely used databases such as Web of Science, Science Direct, Google Scholar, and PubMed using different search strings. A systematic review of the antitumor constituents of the Paeonia genus and their therapeutic effects on various cancers was conducted and the mechanisms of action and pathways of these phytochemicals were summarised to provide a further basis for antitumor research.