牡丹属植物：活性成分、药理作用机制及临床应用的系统综述，用于癌症治疗
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer
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影响因子:7.5
分区:医学2区 / 药物化学1区 药学1区
发表日期:2024 Sep
作者:
Xinrui Zhou, Aikebaier Alimu, Jiarui Zhao, Xinyi Xu, Xiaowen Li, He Lin, Zhe Lin
DOI:
10.1007/s12272-024-01512-2
摘要
牡丹属植物的主要活性成分已被证明具有抗肿瘤活性。已分离出数百种具有广泛药理活性的化合物，包括单萜苷类、类黄酮、单宁、苯乙烯类、三萜类、类固醇和酚类化合物。其中，单萜及其苷类、类黄酮、酚酸等成分显示出对多种癌症的良好治疗效果，其主要作用机制包括诱导细胞凋亡；抑制肿瘤细胞的增殖、迁移和侵袭；以及调节免疫反应。在本研究中，利用Web of Science、Science Direct、Google Scholar和PubMed等广泛使用的数据库，通过不同搜索策略，检索了关于牡丹属植物的传统用途、植物化学成分、抗肿瘤作用及临床应用的相关文献。系统综述了牡丹属植物抗肿瘤成分及其对各种癌症的治疗效果，归纳了这些植物化学物的作用机制和作用途径，为抗肿瘤研究提供了进一步的理论基础。
Abstract
The main active constituents of plants of the Paeonia genus are known to have antitumor activity. Hundreds of compounds with a wide range of pharmacological activities, including monoterpene glycosides, flavonoids, tannins, stilbenes, triterpenoids, steroids, and phenolic compounds have been isolated. Among them, monoterpenes and their glycosides, flavonoids, phenolic acids, and other constituents have been shown to have good therapeutic effects on various cancers, with the main mechanisms including the induction of apoptosis; the inhibition of tumor cell proliferation, migration, and invasion; and the modulation of immunity. In this study, many citations related to the traditional uses, phytochemical constituents, antitumor effects, and clinical applications of the Paeonia genus were retrieved from popular and widely used databases such as Web of Science, Science Direct, Google Scholar, and PubMed using different search strings. A systematic review of the antitumor constituents of the Paeonia genus and their therapeutic effects on various cancers was conducted and the mechanisms of action and pathways of these phytochemicals were summarised to provide a further basis for antitumor research.