神经胶质瘤因其恶性表型、脑实质浸润、瘤内异质性和免疫抑制微环境而成为最具挑战性的肿瘤之一，导致高复发率和惨淡的五年生存率。目前的标准疗法，包括最大程度的肿瘤切除、替莫唑胺化疗和放疗，疗效有限，部分原因是肿瘤细胞抵抗死亡。最近的研究表明，铁死亡是一种新定义的程序性细胞死亡（PCD），在胶质瘤的发生和进展中起着至关重要的作用，并显着影响各种治疗的疗效，代表了一种有前途的治疗策略。在这篇综述中，我们全面概述了铁死亡的最新进展、其在胶质瘤病理生理过程中的参与和调控、各种治疗热点、现有的障碍以及值得研究的未来方向。我们的综述为操纵铁死亡提供了新颖的见解，从而提供了神经胶质瘤治疗的潜在目标和策略。©作者。

Gliomas are one of the most challenging tumors to treat due to their malignant phenotype, brain parenchymal infiltration, intratumoral heterogeneity, and immunosuppressive microenvironment, resulting in a high recurrence rate and dismal five-year survival rate. The current standard therapies, including maximum tumor resection, chemotherapy with temozolomide, and radiotherapy, have exhibited limited efficacy, which is caused partially by the resistance of tumor cell death. Recent studies have revealed that ferroptosis, a newly defined programmed cell death (PCD), plays a crucial role in the occurrence and progression of gliomas and significantly affects the efficacy of various treatments, representing a promising therapeutic strategy. In this review, we provide a comprehensive overview of the latest progress in ferroptosis, its involvement and regulation in the pathophysiological process of gliomas, various treatment hotspots, the existing obstacles, and future directions worth investigating. Our review sheds light on providing novel insights into manipulating ferroptosis to provide potential targets and strategies of glioma treatment.© The author(s).