弥合慢性炎症和消化癌：先天淋巴样细胞在肿瘤微环境中的关键作用
Bridging Chronic Inflammation and Digestive Cancer: The Critical Role of Innate Lymphoid Cells in Tumor Microenvironments
影响因子:10.00000
分区:生物学1区 Top / 生化与分子生物学2区
发表日期:2024
作者:
Guanliang Shen, Qi Wang, Zhengrui Li, Jiaheng Xie, Xinda Han, Zehao Wei, Pengpeng Zhang, Songyun Zhao, Xiumei Wang, Xufeng Huang, Min Xu
摘要
消化系统相关癌症的发病率和死亡率始终很高，并归因于消化系统免疫微环境的异质性和复杂性。此外，几项研究表明，消化系统中的慢性炎症是导致癌症发病率的。因此，控制炎症是阻止癌症发展的潜在策略。先天淋巴样细胞（ILC）代表与T细胞形成对比的一组异质淋巴细胞。它们通过以抗原独立的方式与细胞因子和免疫细胞相互作用来发挥作用。在消化系统癌症中，从炎症阶段到肿瘤的发育，迁移和转移，ILC已被发现与免疫微环境相互作用，并控制或促进这些过程。消化肿瘤的常规治疗方法有限，因此，与ILC相关的免疫疗法是有希望的策略。这项研究回顾了不同ILC亚群的表征，它们如何与免疫微环境以及慢性炎症以及它们在四种常见的消化系统肿瘤中的促销或抑制作用（包括胰腺，结肠直肠癌，胃，胃，胃和肝细胞细胞癌）中的促销或抑制作用。特别是，该综述强调了ILC在将慢性炎症与癌症相关联的作用，以及通过细胞因子疗法和收养免疫细胞疗法增强免疫疗法的潜力。
Abstract
The incidence and mortality of digestive system-related cancers have always been high and attributed to the heterogeneity and complexity of the immune microenvironment of the digestive system. Furthermore, several studies have shown that chronic inflammation in the digestive system is responsible for cancer incidence; therefore, controlling inflammation is a potential strategy to stop the development of cancer. Innate Lymphoid Cells (ILC) represent a heterogeneous group of lymphocytes that exist in contrast to T cells. They function by interacting with cytokines and immune cells in an antigen-independent manner. In the digestive system cancer, from the inflammatory phase to the development, migration, and metastasis of tumors, ILC have been found to interact with the immune microenvironment and either control or promote these processes. The conventional treatments for digestive tumors have limited efficacy, therefore, ILC-associated immunotherapies are promising strategies. This study reviews the characterization of different ILC subpopulations, how they interact with and influence the immune microenvironment as well as chronic inflammation, and their promotional or inhibitory role in four common digestive system tumors, including pancreatic, colorectal, gastric, and hepatocellular cancers. In particular, the review emphasizes the role of ILC in associating chronic inflammation with cancer and the potential for enhanced immunotherapy with cytokine therapy and adoptive immune cell therapy.