Curcumin及其衍生物在调控铁死亡中的潜在作用及机制
Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis
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影响因子:10
分区:生物学1区 Top / 生化与分子生物学2区
发表日期:2024
作者:
Yuan Zhang, Chenghao Yu, Cheng Peng, Fu Peng
DOI:
10.7150/ijbs.90798
摘要
铁死亡是一种新近发现的依赖铁的氧化调控细胞死亡方式。它不仅与多种疾病相关，也是许多信号通路的关键组成部分。总体而言，铁死亡是一把双刃剑，一方面可诱导癌细胞非凋亡性破坏，另一方面可能导致器官损伤。因此，铁死亡可作为药物靶点，用于创新治疗手段。已知姜黄素具有良好的药理特性，能改善癌症和炎症等疾病的治疗效果。本文综述了姜黄素及其衍生物调控铁死亡的机制，主要阐述姜黄素影响铁死亡的途径。结论显示，姜黄素是一种具有出色抗癌作用的铁死亡诱导剂，同时也通过抑制铁死亡发挥器官保护和修复作用。姜黄素对铁死亡的不同调控可能与剂量和细胞类型有关。
Abstract
Ferroptosis is a recently discovered iron-dependent mode of oxidatively regulated cell death. It is not only associated with a wide range of diseases, but it is also a key component of many signaling pathways. In general, ferroptosis is a double-edged sword. On one hand, it induces nonapoptotic destruction of cancer cells, but on the other, it may lead to organ damage. Therefore, ferroptosis can be drug-targeted as a novel means of therapy. The properties of curcumin have been known for many years. It has a positive impact on the treatment of diseases such as cancer and inflammation. In this review, we focus on the regulation of ferroptosis by curcumin and its derivatives and review the main mechanisms by which curcumin affects ferroptosis. In conclusion, curcumin is a ferroptosis inducer with excellent anticancer efficacy, although it also exhibits organ protective and reparative effects by acting as a ferroptosis inhibitor. The differential regulation of ferroptosis by curcumin may be related to dose and cell type.