铁死亡是最近发现的一种铁依赖性氧化调节细胞死亡模式。它不仅与多种疾病相关，而且还是许多信号通路的关键组成部分。一般来说，铁死亡是一把双刃剑。一方面，它诱导癌细胞的非凋亡性破坏，但另一方面，它可能导致器官损伤。因此，铁死亡可以作为一种新的药物靶向治疗手段。姜黄素的特性多年来一直为人所知。它对癌症和炎症等疾病的治疗具有积极的影响。本综述重点关注姜黄素及其衍生物对铁死亡的调节作用，并综述姜黄素影响铁死亡的主要机制。总之，姜黄素是一种铁死亡诱导剂，具有优异的抗癌功效，同时它也通过充当铁死亡抑制剂而表现出器官保护和修复作用。姜黄素对铁死亡的差异调节可能与剂量和细胞类型有关。© 作者。

Ferroptosis is a recently discovered iron-dependent mode of oxidatively regulated cell death. It is not only associated with a wide range of diseases, but it is also a key component of many signaling pathways. In general, ferroptosis is a double-edged sword. On one hand, it induces nonapoptotic destruction of cancer cells, but on the other, it may lead to organ damage. Therefore, ferroptosis can be drug-targeted as a novel means of therapy. The properties of curcumin have been known for many years. It has a positive impact on the treatment of diseases such as cancer and inflammation. In this review, we focus on the regulation of ferroptosis by curcumin and its derivatives and review the main mechanisms by which curcumin affects ferroptosis. In conclusion, curcumin is a ferroptosis inducer with excellent anticancer efficacy, although it also exhibits organ protective and reparative effects by acting as a ferroptosis inhibitor. The differential regulation of ferroptosis by curcumin may be related to dose and cell type.© The author(s).