乳腺癌 (BC) 一直是女性中高度流行的恶性肿瘤，其特点是分子特征多样，需要个性化的治疗方法。铜在生物体内的平衡通过调节吸收、分布和消除得到精心维持，不仅支持细胞平衡，而且支持各种重要的生物功能。铜凋亡过程是由铜与三羧酸 (TCA) 循环内的脂酰化酶相互作用引发的，这会引发脂酰化蛋白质的聚集并降低 Fe-S 簇的完整性，最终通过蛋白毒性应激导致细胞死亡。在 BC，铜凋亡的畸变很突出，代表了导致疾病进展的关键分子事件。它影响 BC 细胞代谢并影响增殖、侵袭性和化疗耐药性等关键特征。针对铜凋亡的治疗策略已显示出有希望的抗肿瘤功效。此外，已经鉴定了大量以铜凋亡为中心的基因，包括铜凋亡相关基因（CRG）、CRG相关非编码RNA（ncRNA）和铜凋亡相关调节因子，为开发风险评估模型或诊断签名。在这篇综述中，我们全面阐述了铜凋亡的基本原理、其对乳腺癌恶性表型的影响、基于铜凋亡的标志物的预后意义以及利用铜凋亡治疗乳腺癌的巨大前景，从而奠定了理论基础。在此领域进行有针对性的干预。© 作者。

Breast cancer (BC) persists as a highly prevalent malignancy in females, characterized by diverse molecular signatures and necessitating personalized therapeutic approaches. The equilibrium of copper within the organism is meticulously maintained through regulated absorption, distribution, and elimination, underpinning not only cellular equilibrium but also various essential biological functions. The process of cuproptosis is initiated by copper's interaction with lipoylases within the tricarboxylic acid (TCA) cycle, which triggers the conglomeration of lipoylated proteins and diminishes the integrity of Fe-S clusters, culminating in cell demise through proteotoxic stress. In BC, aberrations in cuproptosis are prominent and represent a crucial molecular incident that contributes to the disease progression. It influences BC cell metabolism and affects critical traits such as proliferation, invasiveness, and resistance to chemotherapy. Therapeutic strategies that target cuproptosis have shown promising antitumor efficacy. Moreover, a plethora of cuproptosis-centric genes, including cuproptosis-related genes (CRGs), CRG-associated non-coding RNAs (ncRNAs), and cuproptosis-associated regulators, have been identified, offering potential for the development of risk assessment models or diagnostic signatures. In this review, we provide a comprehensive exposition of the fundamental principles of cuproptosis, its influence on the malignant phenotypes of BC, the prognostic implications of cuproptosis-based markers, and the substantial prospects of exploiting cuproptosis for BC therapy, thereby laying a theoretical foundation for targeted interventions in this domain.© The author(s).