癌症和代谢疾病中的抗氧化基因：专注于NRF2，Sestrin和血红素加氧酶1
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1
影响因子:10.00000
分区:生物学1区 Top / 生化与分子生物学2区
发表日期:2024
作者:
Jitendra Shrestha, Khem Raj Limbu, Rashmi Bhandari Chhetri, Keshav Raj Paudel, Philip M Hansbro, Yoon Sin Oh, Dong Jae Baek, Sung-Hwan Ki, Eun-Young Park
摘要
活性氧与包括糖尿病，肥胖和脂肪肝病在内的癌症和代谢疾病的发病机理有关。因此，抑制自由基的产生是控制代谢疾病和癌症进展的有前途的策略。据报道，各种抗氧化活性的合成药物和天然产物衍生的化合物对各种代谢疾病和癌症具有保护作用。这篇评论强调了由于促氧化剂和内源性抗氧化剂分子之间的不平衡，癌症和代谢疾病的发育和加剧。此外，我们讨论了调节活性氧作为治疗代谢疾病的策略的蛋白质的功能。特别是，我们总结了蛋白质（例如核因子样2，sestrin和heme氧酶-1）的作用，这些蛋白质在代谢性疾病和癌症中调节各种抗氧化基因的表达。我们包括最近的文献，讨论了有关鉴定可以控制代谢疾病和癌症的抗氧化基因的新信号的最新研究。
Abstract
Reactive oxygen species are involved in the pathogenesis of cancers and metabolic diseases, including diabetes, obesity, and fatty liver disease. Thus, inhibiting the generation of free radicals is a promising strategy to control the onset of metabolic diseases and cancer progression. Various synthetic drugs and natural product-derived compounds that exhibit antioxidant activity have been reported to have a protective effect against a range of metabolic diseases and cancer. This review highlights the development and aggravation of cancer and metabolic diseases due to the imbalance between pro-oxidants and endogenous antioxidant molecules. In addition, we discuss the function of proteins that regulate the production of reactive oxygen species as a strategy to treat metabolic diseases. In particular, we summarize the role of proteins such as nuclear factor-like 2, Sestrin, and heme oxygenase-1, which regulate the expression of various antioxidant genes in metabolic diseases and cancer. We have included recent literature to discuss the latest research on identifying novel signals of antioxidant genes that can control metabolic diseases and cancer.