癌症及代谢疾病中的抗氧化基因：聚焦于Nrf2、Sestrin及血红素氧合酶1
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1
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影响因子:10
分区:生物学1区 Top / 生化与分子生物学2区
发表日期:2024
作者:
Jitendra Shrestha, Khem Raj Limbu, Rashmi Bhandari Chhetri, Keshav Raj Paudel, Philip M Hansbro, Yoon Sin Oh, Dong Jae Baek, Sung-Hwan Ki, Eun-Young Park
DOI:
10.7150/ijbs.98846
摘要
活性氧（ROS）在癌症和代谢性疾病的发病机制中扮演重要角色，包括糖尿病、肥胖和脂肪肝疾病。因此，抑制自由基的生成是控制代谢疾病和癌症发展的有效策略。多种具有抗氧化活性的合成药物和天然产物已被报道具有保护作用，可防止多种代谢性疾病和癌症的发生。本综述强调了在促氧化剂与内源性抗氧化分子失衡情况下癌症和代谢疾病的发生和加重。我们还讨论了调节活性氧产生的蛋白质在治疗代谢疾病中的作用，特别总结了核因子样2（Nrf2）、Sestrin和血红素氧合酶-1等蛋白在调控抗氧化基因表达中的作用，为开发新型抗氧化信号通路提供了基础。最新研究动态也被囊括，旨在揭示调控代谢疾病和癌症的抗氧化基因信号的新发现。
Abstract
Reactive oxygen species are involved in the pathogenesis of cancers and metabolic diseases, including diabetes, obesity, and fatty liver disease. Thus, inhibiting the generation of free radicals is a promising strategy to control the onset of metabolic diseases and cancer progression. Various synthetic drugs and natural product-derived compounds that exhibit antioxidant activity have been reported to have a protective effect against a range of metabolic diseases and cancer. This review highlights the development and aggravation of cancer and metabolic diseases due to the imbalance between pro-oxidants and endogenous antioxidant molecules. In addition, we discuss the function of proteins that regulate the production of reactive oxygen species as a strategy to treat metabolic diseases. In particular, we summarize the role of proteins such as nuclear factor-like 2, Sestrin, and heme oxygenase-1, which regulate the expression of various antioxidant genes in metabolic diseases and cancer. We have included recent literature to discuss the latest research on identifying novel signals of antioxidant genes that can control metabolic diseases and cancer.