肺癌在全球范围内非常流行，是癌症相关死亡的主要原因，由于缺乏用于早期诊断和个性化治疗干预的明确肿瘤标志物，肺癌仍然是一个重大挑战。近年来，细胞外囊泡（EV）作为细胞间通讯的天然载体，由于其能够穿越生物屏障并递送多种生物货物（包括胞质蛋白、细胞表面蛋白、microRNA、lncRNA、circRNA、DNA）而受到越来越多的关注。和脂质。 EV 越来越被认为是无创液体活检、药物输送平台和肺癌精准医疗抗癌疫苗的宝贵资源。在此，考虑到肿瘤相关 EV 对肺癌的诊断和治疗潜力，我们从转化的角度讨论了这个话题。我们深入研究了 EV 在肺癌致癌过程中发挥的具体作用，并就先进工程技术如何克服当前挑战并加速和/或增强 EV 从实验室研究到临床环境的转化提供了特殊的视角。© 2024 作者。

Lung cancer, highly prevalent and the leading cause of cancer-related death globally, persists as a significant challenge due to the lack of definitive tumor markers for early diagnosis and personalized therapeutic interventions. Recently, extracellular vesicles (EVs), functioning as natural carriers for intercellular communication, have received increasing attention due to their ability to traverse biological barriers and deliver diverse biological cargoes, including cytosolic proteins, cell surface proteins, microRNA, lncRNA, circRNA, DNA, and lipids. EVs are increasingly recognized as a valuable resource for non-invasive liquid biopsy, as well as drug delivery platforms, and anticancer vaccines for precision medicine in lung cancer. Herein, given the diagnostic and therapeutic potential of tumor-associated EVs for lung cancer, we discuss this topic from a translational standpoint. We delve into the specific roles that EVs play in lung cancer carcinogenesis and offer a particular perspective on how advanced engineering technologies can overcome the current challenges and expedite and/or enhance the translation of EVs from laboratory research to clinical settings.© 2024 The Authors.