外泌体是一种细胞外囊泡，富含各种非编码 RNA (ncRNA)，已成为细胞间通讯的重要介质。外泌体 nc​​RNA 的稳定性、丰度和特异性使其成为生物标志物发现的有希望的候选者。外泌体 nc​​RNA 的发现为探索肿瘤早期诊断中的生物标志物开辟了一条新途径。这篇综述巩固了目前关于外泌体 nc​​RNA 作为潜在生物标志物在各种肿瘤早期检测中的作用的知识。我们概述了最近的研究，这些研究证明了外泌体 nc​​RNA 在多种癌症类型中的诊断潜力，强调了它们的敏感性、特异性和早期检测的可行性。本综述强调了外泌体 nc​​RNA 作为早期肿瘤诊断的非侵入性生物标志物的潜力，为通过及时干预和个性化管理策略改善临床结果铺平了道路。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

Exosomes, extracellular vesicles carrying a cargo rich in various non-coding RNAs (ncRNAs), have emerged as crucial mediators of intercellular communication. Their stability, abundance, and specificity make exosomal ncRNAs promising candidates for biomarker discovery. The discovery of exosomal ncRNAs has unveiled a novel avenue for the exploration of biomarkers in tumor early diagnosis. This review consolidates current knowledge on the role of exosomal ncRNAs as potential biomarkers in the early detection of various tumors. We provide an overview of recent studies demonstrating the diagnostic potential of exosomal ncRNAs across multiple cancer types, highlighting their sensitivity, specificity, and feasibility for early detection. This review underscores the potential of exosomal ncRNAs as non-invasive biomarkers for early tumor diagnosis, paving the way for improved clinical outcomes through timely intervention and personalized management strategies.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.