口服白细胞的恶性转化：系统评价和全面的荟萃分析
Malignant transformation of oral leukoplakia: Systematic review and comprehensive meta-analysis
影响因子:2.90000
分区:医学3区 / 牙科与口腔外科4区
发表日期:2025 Jan
作者:
Liliana Aparecida Pimenta-Barros, Pablo Ramos-García, Miguel Ángel González-Moles, José Manuel Aguirre-Urizar, Saman Warnakulasuriya
摘要
为了更新有关口腔白细胞（OL）恶性转变的当前证据，包括全球发表的有关该主题的所有研究，以最大的严格性而挑选出有关资格的最大严格性。Medline，Embase，Web of Science和Scopus均在6月至20124年6月至2014年之前发表的研究，没有较低的日期限制。使用乔安娜·布里格斯研究所（Joanna Briggs Institute Institute）工具分析了偏见的风险。我们进行了荟萃分析，探索了亚组之间的异质性，并确定了具有潜在预后价值的风险因素。五十五项研究（41,231 with with ol）。 OL的合并恶性转化比例为6.64％（95％CI = 5.21-8.21）。恶性转化并未因时间段（p = 0.75）的显着变化，在1978年之前为5.35％，从1979年到2007年为7.06％，最近的时间为6.97％。 The risk factors that significantly had a higher impact on malignant transformation were the non-homogeneous leukoplakias (RR = 4.23, 95% CI = 3.31-5.39, p < 0.001), the larger size (RR = 2.08, 1.45-2.96, p < 0.001), leukoplakia located on the lateral border of tongue (malignant transformation = 12.71%; RR = 2.09，95％CI = 1.48-2.95，P <0.001），吸烟（RR = 1.64，95％CI = 1.25-2.15，P <0.001），以及上皮性发育不全的存在（RR = 2.75，95％CI = 2.26-3.35，P <0.001）。在舌头外侧边界上的吸烟者的大型非殖民病病变中，上皮发育不良。
Abstract
To update the current evidence on the malignant transformation of oral leukoplakia (OL), including all studies published worldwide on the subject, selected with the maximum rigor regarding eligibility.MEDLINE, Embase, Web of Science and Scopus were searched for studies published before June-2024, with no lower date limit. The risk of bias was analyzed using the Joanna Briggs Institute tool for meta-analyses of proportions. We carried out meta-analyses, explored heterogeneity across subgroups and identified risk factors with potential prognostic value.Fifty-five studies (41,231 with OL) were included. The pooled malignant transformation proportion for OL was 6.64% (95% CI = 5.21-8.21). The malignant transformation did not significantly vary by time periods (p = 0.75), 5.35% prior to 1978, 7.06% from 1979 to 2007 and 6.97% during more recent times. The risk factors that significantly had a higher impact on malignant transformation were the non-homogeneous leukoplakias (RR = 4.23, 95% CI = 3.31-5.39, p < 0.001), the larger size (RR = 2.08, 1.45-2.96, p < 0.001), leukoplakia located on the lateral border of tongue (malignant transformation = 12.71%; RR = 2.09, 95% CI = 1.48-2.95, p < 0.001), smoking (RR = 1.64, 95% CI = 1.25-2.15, p < 0.001), and the presence of epithelial dysplasia (RR = 2.75, 95% CI = 2.26-3.35, p < 0.001).OL presents a considerable malignant transformation probability that is especially increased in large non-homogeneous lesions in smokers, located on the lateral border of the tongue, with epithelial dysplasia.