富含microRNA的外泌体作为癌症和免疫细胞之间的舞蹈家
MicroRNA-enriched exosome as dazzling dancer between cancer and immune cells
影响因子:4.30000
分区:生物学3区 / 生化与分子生物学3区 生理学3区
发表日期:2024 Nov
作者:
Chou-Yi Hsu, Abdulrahman T Ahmed, Pooja Bansal, Ahmed Hjazi, Hussein Riyadh Abdul Kareem Al-Hetty, Maytham T Qasim, Ibrokhim Sapaev, Mahamedha Deorari, Yasser Fakri Mustafa, Ahmed Elawady
摘要
外泌体在众多生物学过程中和细胞间通信介体中的作用被广泛认可。人癌和正常细胞都可以产生大量的外泌体。它们广泛分散在癌症患者的肿瘤模型动物的胸腔积液，腹水和血浆中。肿瘤细胞通过释放外泌体与宿主细胞相互作用，从而使它们可以互换各种生物学成分。肿瘤生长，侵袭，转移甚至肿瘤发生都可以通过修改附近和偏远的环境来促进这种精致而复杂的系统。由于存在明显水平的生物分子，例如microRNA，外泌体可以调节免疫系统的刺激或抑制，从而控制肿瘤的生长。但是，microRNA在免疫学和癌细胞之间在外泌体介导的通信中的作用仍然很少了解。这项研究旨在获取有关调节肿瘤免疫和免疫疗法的外泌体microRNA“阳和阳”的最新信息，这将有助于当前的癌症治疗和诊断技术。
Abstract
Exosomes are widely recognized for their roles in numerous biological processes and as intercellular communication mediators. Human cancerous and normal cells can both produce massive amounts of exosomes. They are extensively dispersed in tumor-modeling animals' pleural effusions, ascites, and plasma from people with cancer. Tumor cells interact with host cells by releasing exosomes, which allow them to interchange various biological components. Tumor growth, invasion, metastasis, and even tumorigenesis can all be facilitated by this delicate and complex system by modifying the nearby and remote surroundings. Due to the existence of significant levels of biomolecules like microRNA, exosomes can modulate the immune system's stimulation or repression, which in turn controls tumor growth. However, the role of microRNA in exosome-mediated communication between immunological and cancer cells is still poorly understood. This study aims to get the most recent information on the "yin and yang" of exosomal microRNA in the regulation of tumor immunity and immunotherapy, which will aid current cancer treatment and diagnostic techniques.