细胞间粘附分子-1 (ICAM-1) 是一种多功能分子，在各种生理和病理过程中发挥着关键作用，特别是在肿瘤发展中，其影响是双向的。一方面，它通过促进免疫细胞迁移、浸润和免疫突触的形成来增强免疫反应，从而促进有效的抗肿瘤作用。同时，它通过介导肿瘤细胞的跨内皮迁移（TEM）、上皮间质转化（EMT）和表观遗传修饰，有助于肿瘤免疫逃避并影响转移。尽管潜力巨大，但 ICAM-1 的全部临床效用尚未完全实现。在这篇综述中，我们深入研究了了解 ICAM-1 在肿瘤发展中的作用、其在预测治疗效果和预后方面的相关性以及基于抗 ICAM-1 的疗法的临床转化研究进展的最新进展，包括包括单克隆抗体、免疫疗法、抗体药物偶联物 (ADC) 和常规治疗。通过阐明这些创新策略，我们旨在强调 ICAM-1 作为癌症治疗的有价值的多方面靶点的重要性，激发进一步研究的热情并促进转化为临床应用。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Intercellular adhesion molecule-1 (ICAM-1) is a versatile molecule that plays a critical role in various physiological and pathological processes, particularly in tumor development where its impact is bidirectional. On the one hand, it augments the immune response by promoting immune cell migration, infiltration, and the formation of immunological synapses, thus facilitating potent antitumor effects. Simultaneously, it contributes to tumor immune evasion and influences metastasis by mediating transendothelial migration (TEM), epithelial-to-mesenchymal transition (EMT), and epigenetic modification of tumor cells. Despite its significant potential, the full clinical utility of ICAM-1 has yet to be fully realized. In this review, we thoroughly examine recent advancements in understanding the role of ICAM-1 in tumor development, its relevance in predicting therapeutic efficacy and prognosis, as well as the progress in clinical translational research on anti-ICAM-1-based therapies, encompassing including monoclonal antibodies, immunotherapy, antibody-drug conjugate (ADC), and conventional treatments. By shedding light on these innovative strategies, we aim to underscore ICAM-1's significance as a valuable and multifaceted target for cancer treatment, igniting enthusiasm for further research and facilitating translation into clinical applications.Copyright © 2024 Elsevier B.V. All rights reserved.